Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK2 | Q15119 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 5/20 | 0.40 |
| ▸ | RARB | P10826 | 1/20 | 0.39 |
| ▸ | RARG | P13631 | 1/20 | 0.39 |
| ▸ | CASP3 | P42574 | 1/20 | 0.38 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.38 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.38 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.38 |
| ▸ | CDC25B | P30305 | 2/20 | 0.38 |
| ▸ | PTPRC | P08575 | 1/20 | 0.38 |
| ▸ | PTPRF | P10586 | 1/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13041368 | 0.77 | RAB9A (0.49) | RAB9ANPC1SMN1; SMN2TSHRMAPT | |
| SCHEMBL6982305 | 0.75 | ALDH1A1 (0.43) | PDK2MAPTL3MBTL1ALDH1A1ITGA4 | |
| SCHEMBL23883482 | 0.73 | RAB9A (0.54) | RAB9ANPC1SMN1; SMN2TSHRMAPT | |
| SCHEMBL6968252 | 0.72 | MEN1 (0.42) | SMN1; SMN2MAPTL3MBTL1ALDH1A1ITGA4 | |
| SCHEMBL25364240 | 0.71 | TSHR (0.55) | RAB9ANPC1SMN1; SMN2TSHRMAPT | |
| SCHEMBL28831179 | 0.70 | PDK2 (0.48) | PDK2RAB9ANPC1SMN1; SMN2TSHR | |
| SCHEMBL6982212 | 0.70 | THRB (0.46) | PDK2MAPTRARBRARGL3MBTL1 | |
| SCHEMBL6971971 | 0.69 | NPC1 (0.44) | PDK2RAB9ANPC1MAPTALDH1A1 | |
| SCHEMBL31522049 | 0.68 | TSHR (0.60) | RAB9ANPC1SMN1; SMN2TSHRMAPT | |
| SCHEMBL6981621 | 0.68 | APEX1 (0.42) | TSHRMAPTALDH1A1ITGA4TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1098893-B1 | CYCLIC COMPOUNDS USEFUL IN THE TREATMENT OF DYSLIPIDEMIA, ATHEROSCLEROSIS AND DIABETES, PHARMACEUTICAL COMPOSITIONS AND PREPARATION PROCESS | MERCK PATENT GMBH (DE) | 2003-03-26 | — | — | EP | disclosed |