Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 4/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | PDK2 | Q15119 | 4/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6982212 | 0.83 | THRB (0.46) | ALDH1A1MAPTITGA4MEN1KMT2A | |
| SCHEMBL6979914 | 0.81 | MEN1 (0.51) | MEN1KMT2AHTTLMNAL3MBTL1 | |
| SCHEMBL6968252 | 0.81 | MEN1 (0.42) | ALDH1A1MAPTITGA4MEN1KMT2A | |
| SCHEMBL6973943 | 0.75 | PDK2 (0.44) | ALDH1A1MAPTITGA4MEN1KMT2A | |
| SCHEMBL6981621 | 0.74 | APEX1 (0.42) | ALDH1A1MAPTITGA4KMT2AHTT | |
| SCHEMBL7816054 | 0.73 | ALDH1A1 (0.37) | ALDH1A1MAPTITGA4MEN1KMT2A | |
| SCHEMBL4217613 | 0.73 | ALDH1A1 (0.49) | ALDH1A1MAPTITGA4MEN1KMT2A | |
| SCHEMBL6975654 | 0.72 | MAPT (0.40) | ALDH1A1MAPTITGA4MEN1KMT2A | |
| SCHEMBL14026066 | 0.71 | ALDH1A1 (0.50) | ALDH1A1MAPTITGA4MEN1KMT2A | |
| SCHEMBL30204529 | 0.71 | ALDH1A1 (0.50) | ALDH1A1MAPTITGA4MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1098893-B1 | CYCLIC COMPOUNDS USEFUL IN THE TREATMENT OF DYSLIPIDEMIA, ATHEROSCLEROSIS AND DIABETES, PHARMACEUTICAL COMPOSITIONS AND PREPARATION PROCESS | MERCK PATENT GMBH (DE) | 2003-03-26 | — | — | EP | disclosed |