Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | APEX1 | P27695 | 1/20 | 0.38 |
| ▸ | PDK2 | Q15119 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | PPARA | Q07869 | 2/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | FPR2 | P25090 | 1/20 | 0.33 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | RARB | P10826 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6982305 | 0.83 | ALDH1A1 (0.43) | THRBTDP1PDK2ALDH1A1MAPT | |
| SCHEMBL7815888 | 0.83 | GAA (0.42) | PDK2ALDH1A1MAPTL3MBTL1LMNA | |
| SCHEMBL6982070 | 0.81 | AKR1C1 (0.40) | ALDH1A1MAPTKMT2AMEN1ADRB2 | |
| SCHEMBL6981621 | 0.81 | APEX1 (0.42) | THRBTDP1APEX1ALDH1A1MAPT | |
| SCHEMBL6982681 | 0.79 | THRB (0.44) | THRBTDP1APEX1PDK2ALDH1A1 | |
| SCHEMBL1818484 | 0.73 | THRB (0.50) | THRBTDP1APEX1PDK2ALDH1A1 | |
| SCHEMBL6971971 | 0.73 | NPC1 (0.44) | PDK2ALDH1A1MAPTKMT2APOLB | |
| SCHEMBL6971210 | 0.73 | CYP1A2 (0.41) | THRBTDP1KMT2AMEN1NPSR1 | |
| SCHEMBL6968252 | 0.73 | MEN1 (0.42) | THRBTDP1ALDH1A1MAPTITGA4 | |
| SCHEMBL6981485 | 0.72 | THRB (0.38) | THRBTDP1APEX1PDK2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1098893-B1 | CYCLIC COMPOUNDS USEFUL IN THE TREATMENT OF DYSLIPIDEMIA, ATHEROSCLEROSIS AND DIABETES, PHARMACEUTICAL COMPOSITIONS AND PREPARATION PROCESS | MERCK PATENT GMBH (DE) | 2003-03-26 | — | — | EP | disclosed |