Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | NAMPT | P43490 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | APOB | P04114 | 7/20 | 0.41 |
| ▸ | MTTP | P55157 | 6/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | PPARD | Q03181 | 1/20 | 0.41 |
| ▸ | PPARA | Q07869 | 1/20 | 0.41 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6962034 | 0.85 | APOB (0.44) | HDAC6GAASMN1; SMN2NAMPTMAPT | |
| SCHEMBL6962760 | 0.85 | APOB (0.44) | HDAC6GAASMN1; SMN2NAMPTKDM4E | |
| SCHEMBL8473043 | 0.83 | HDAC6 (0.42) | HDAC6GAASMN1; SMN2NAMPTMAPT | |
| SCHEMBL6974835 | 0.78 | ABCB1 (0.48) | SMN1; SMN2MAPTKDM4EALDH1A1LMNA | |
| SCHEMBL6969471 | 0.78 | KEAP1 (0.44) | HDAC6GAANAMPTMAPTAPOB | |
| SCHEMBL6964486 | 0.78 | PLAU (0.46) | GAAMAPTAPOBMTTPKMT2A | |
| SCHEMBL6962135 | 0.77 | GAA (0.60) | HDAC6GAASMN1; SMN2MAPTKDM4E | |
| SCHEMBL6974444 | 0.77 | KDM4E (0.44) | GAAMAPTKDM4EALDH1A1APOB | |
| SCHEMBL6973499 | 0.77 | SMO (0.45) | APOBMTTP | |
| SCHEMBL6970162 | 0.77 | NAMPT (0.47) | NAMPTKDM4EAPOBMTTP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0832069-B1 | BIPHENYL-2-CARBOXYLIC ACID-TETRAHYDRO-ISOQUINOLIN-6-YL AMIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS INHIBITORS OF MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN AND/OR APOLIPOPROTEIN B (Apo B) SECRETION | PFIZER (US) | 2003-03-05 | — | — | EP | claimed |