Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | APEX1 | P27695 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.37 |
| ▸ | CRHBP | P24387 | 1/20 | 0.37 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | CASP6 | P55212 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | PDK2 | Q15119 | 4/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | CFTR | P13569 | 1/20 | 0.33 |
| ▸ | GOPC | Q9HD26 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | EDNRB | P24530 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7816054 | 0.81 | ALDH1A1 (0.37) | KMT2AALDH1A1MAPTITGA4L3MBTL1 | |
| SCHEMBL6981034 | 0.80 | L3MBTL1 (0.43) | KMT2AALDH1A1POLBCASP6SMN1; SMN2 | |
| SCHEMBL7813440 | 0.74 | MAPT (0.41) | TDP1KMT2AALDH1A1MAPTITGA4 | |
| SCHEMBL7812040 | 0.74 | MAPT (0.38) | TDP1KMT2AALDH1A1MAPTITGA4 | |
| SCHEMBL6981442 | 0.73 | L3MBTL1 (0.41) | TDP1KMT2AALDH1A1MAPTITGA4 | |
| SCHEMBL6982212 | 0.71 | THRB (0.46) | THRBTDP1KMT2AAPEX1ALDH1A1 | |
| SCHEMBL16868730 | 0.71 | PDK2 (0.38) | THRBTDP1KMT2AAPEX1ALDH1A1 | |
| SCHEMBL6982681 | 0.70 | THRB (0.44) | THRBTDP1KMT2AAPEX1ALDH1A1 | |
| SCHEMBL6981621 | 0.69 | APEX1 (0.42) | THRBTDP1KMT2AAPEX1ALDH1A1 | |
| SCHEMBL9868039 | 0.66 | CYP2C19 (0.38) | KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1098893-B1 | CYCLIC COMPOUNDS USEFUL IN THE TREATMENT OF DYSLIPIDEMIA, ATHEROSCLEROSIS AND DIABETES, PHARMACEUTICAL COMPOSITIONS AND PREPARATION PROCESS | MERCK PATENT GMBH (DE) | 2003-03-26 | — | — | EP | disclosed |