Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CASP6 | P55212 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6974639 | 0.80 | THRB (0.43) | L3MBTL1POLBCASP6KMT2ASMN1; SMN2 | |
| SCHEMBL6983038 | 0.77 | L3MBTL1 (0.56) | L3MBTL1MEN1KMT2AALDH1A1HTT | |
| SCHEMBL28117468 | 0.73 | L3MBTL1 (0.40) | L3MBTL1MEN1KMT2ACYP2C9MAPK1 | |
| SCHEMBL6981785 | 0.73 | CYP2C9 (0.44) | L3MBTL1POLBMEN1KMT2ACYP2C9 | |
| SCHEMBL12488444 | 0.69 | OPRM1 (0.46) | MEN1KMT2ACYP2C9MAPK1SMN1; SMN2 | |
| SCHEMBL9868039 | 0.69 | CYP2C19 (0.38) | MEN1KMT2ACYP2C19 | |
| SCHEMBL11463005 | 0.69 | CYP2D6 (0.42) | L3MBTL1MEN1KMT2ACYP2C9MAPK1 | |
| SCHEMBL6981777 | 0.69 | AKR1C1 (0.41) | L3MBTL1MEN1KMT2ACYP2C9MAPK1 | |
| SCHEMBL12893253 | 0.69 | ESR2 (0.42) | L3MBTL1MEN1KMT2AALDH1A1OPRM1 | |
| SCHEMBL14294601 | 0.68 | L3MBTL1 (0.39) | L3MBTL1MEN1KMT2ACYP2C9MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1098893-B1 | CYCLIC COMPOUNDS USEFUL IN THE TREATMENT OF DYSLIPIDEMIA, ATHEROSCLEROSIS AND DIABETES, PHARMACEUTICAL COMPOSITIONS AND PREPARATION PROCESS | MERCK PATENT GMBH (DE) | 2003-03-26 | — | — | EP | disclosed |
| EP-1098893-A1 | CYCLIC COMPOUNDS USEFUL IN THE TREATMENT OF DYSLIPIDEMIA, ATHEROSCLEROSIS AND DIABETES, PHARMACEUTICAL COMPOSITIONS AND PREPARATION PROCESS | MERCK PATENT GmbH (DE) | 2001-05-16 | — | — | EP | disclosed |
| WO-2000004011-A1 | CYCLIC COMPOUNDS USEFUL IN THE TREATMENT OF DYSLIPIDAEMIA, ATHEROSCLEROSIS AND DIABETES, PHARMACEUTICAL COMPOSITIONS AND PREPARATION PROCESS | MERCK PATENT GMBH (DE) | 2000-01-27 | — | — | WO | disclosed |