Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 8/20 | 0.44 |
| ▸ | APOB | P04114 | 3/20 | 0.40 |
| ▸ | MTTP | P55157 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TNF | P01375 | 1/20 | 0.38 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.38 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6974835 | 0.89 | ABCB1 (0.48) | ABCB1APOBMTTPMEN1KMT2A | |
| SCHEMBL6973828 | 0.88 | UBE2M (0.45) | ABCB1APOBMTTPMEN1KMT2A | |
| SCHEMBL6974687 | 0.84 | ABCB1 (0.41) | ABCB1APOBMTTPMEN1KMT2A | |
| SCHEMBL6973499 | 0.83 | SMO (0.45) | ABCB1APOBMTTPTNFNOD2 | |
| SCHEMBL6974444 | 0.82 | KDM4E (0.44) | ABCB1APOBMTTPALDH1A1KDM4E | |
| SCHEMBL8470454 | 0.81 | ENPP2 (0.41) | ABCB1MEN1KMT2AMAPK1ALDH1A1 | |
| SCHEMBL6965865 | 0.81 | APOB (0.41) | ABCB1APOBMTTPMEN1KMT2A | |
| SCHEMBL6974667 | 0.81 | MEN1 (0.49) | ABCB1APOBMTTPMEN1KMT2A | |
| SCHEMBL6964489 | 0.81 | SMO (0.50) | APOBMTTP | |
| SCHEMBL6964486 | 0.81 | PLAU (0.46) | APOBMTTPKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0832069-B1 | BIPHENYL-2-CARBOXYLIC ACID-TETRAHYDRO-ISOQUINOLIN-6-YL AMIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS INHIBITORS OF MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN AND/OR APOLIPOPROTEIN B (Apo B) SECRETION | PFIZER (US) | 2003-03-05 | — | — | EP | claimed |