Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | ACACB | O00763 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | FAAH | O00519 | 1/20 | 0.36 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.36 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.35 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.35 |
| ▸ | CASR | P41180 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6976795 | 0.86 | KMT2A (0.47) | KMT2AMEN1SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL6984711 | 0.82 | RAB9A (0.42) | KMT2AMEN1SMN1; SMN2ALDH1A1RAB9A | |
| SCHEMBL6171559 | 0.74 | ALDH1A1 (0.40) | KMT2AMEN1ALDH1A1RAB9ATSHR | |
| SCHEMBL19353009 | 0.74 | KMT2A (0.51) | KMT2AMEN1SMN1; SMN2ALDH1A1RAB9A | |
| SCHEMBL6984916 | 0.72 | KMT2A (0.41) | KMT2AMEN1ALDH1A1RAB9ATSHR | |
| SCHEMBL6985419 | 0.72 | KMT2A (0.41) | KMT2AMEN1ALDH1A1RAB9ATSHR | |
| SCHEMBL4876123 | 0.71 | ACACB (0.41) | KMT2AMEN1SMN1; SMN2ACACBALDH1A1 | |
| SCHEMBL6982440 | 0.71 | PDK1 (0.41) | KMT2AMEN1SMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL23219754 | 0.66 | KMT2A (0.43) | KMT2AMEN1SMN1; SMN2ALDH1A1RAB9A | |
| SCHEMBL5098402 | 0.66 | KMT2A (0.62) | KMT2AMEN1SMN1; SMN2ACACBRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1289965-A1 | SUBSTITUTED 1-AMINOALKYL-LACTAMS AND THEIR USE AS MUSCARINIC RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2003-03-12 | — | — | EP | disclosed |
| WO-2001090081-A1 | SUBSTITUTED 1-AMINOALKYL-LACTAMS AND THEIR USE AS MUSCARINIC RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2001-11-29 | — | — | WO | disclosed |