Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.38 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.38 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.38 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6984916 | 1.00 | KMT2A (0.41) | KMT2APOLBTDP1ALDH1A1KDM4E | |
| SCHEMBL6982440 | 0.88 | PDK1 (0.41) | KMT2APOLBTDP1ALDH1A1KDM4E | |
| SCHEMBL6173963 | 0.88 | LMNA (0.39) | KMT2APOLBTDP1ALDH1A1MEN1 | |
| SCHEMBL6171559 | 0.88 | ALDH1A1 (0.40) | KMT2APOLBTDP1ALDH1A1KDM4E | |
| SCHEMBL6985640 | 0.86 | POLB (0.41) | KMT2APOLBTDP1ALDH1A1KDM4E | |
| SCHEMBL6986506 | 0.85 | SMN1; SMN2 (0.37) | KMT2APOLBTDP1ALDH1A1KDM4E | |
| SCHEMBL6175426 | 0.84 | MEN1 (0.45) | KMT2APOLBALDH1A1RAB9AMEN1 | |
| SCHEMBL6173064 | 0.84 | CCR2 (0.33) | KMT2APOLBTDP1ALDH1A1PDK1 | |
| SCHEMBL7085949 | 0.82 | PDK1 (0.35) | KMT2AALDH1A1RAB9APDK1PDK2 | |
| SCHEMBL7088516 | 0.80 | GPR119 (0.45) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1289965-A1 | SUBSTITUTED 1-AMINOALKYL-LACTAMS AND THEIR USE AS MUSCARINIC RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2003-03-12 | — | — | EP | disclosed |
| WO-2001090081-A1 | SUBSTITUTED 1-AMINOALKYL-LACTAMS AND THEIR USE AS MUSCARINIC RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2001-11-29 | — | — | WO | disclosed |