Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APOB | P04114 | 13/20 | 0.41 |
| ▸ | MTTP | P55157 | 12/20 | 0.41 |
| ▸ | FAAH | O00519 | 1/20 | 0.36 |
| ▸ | MGLL | Q99685 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | F10 | P00742 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6973825 | 0.86 | APOB (0.41) | APOBMTTPFAAHMGLLGAA | |
| SCHEMBL6964506 | 0.86 | APOB (0.44) | APOBMTTPMGLL | |
| SCHEMBL6975613 | 0.84 | APOB (0.43) | APOBMTTPMGLLGAAMAPT | |
| SCHEMBL6974219 | 0.83 | F10 (0.42) | APOBMTTPMGLLGAAMAPT | |
| Xenalipin SCHEMBL9093534 | 0.78 | MTTP (0.37) | APOBMTTP | |
| SCHEMBL8025148 | 0.76 | APOB (0.48) | APOBMTTP | |
| SCHEMBL6970162 | 0.75 | NAMPT (0.47) | APOBMTTP | |
| SCHEMBL6966377 | 0.73 | APOB (0.44) | APOBMTTP | |
| SCHEMBL8472708 | 0.71 | APOB (0.52) | APOBMTTPGAAMAPT | |
| SCHEMBL8211362 | 0.70 | MTTP (0.54) | APOBMTTP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0832069-B1 | BIPHENYL-2-CARBOXYLIC ACID-TETRAHYDRO-ISOQUINOLIN-6-YL AMIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS INHIBITORS OF MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN AND/OR APOLIPOPROTEIN B (Apo B) SECRETION | PFIZER (US) | 2003-03-05 | — | — | EP | claimed |