Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 11/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | HTR7 | P34969 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.35 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6977822 | 0.90 | MAPT (0.49) | HTR6ALDH1A1MAPTPOLBSMN1; SMN2 | |
| SCHEMBL6967255 | 0.84 | AKR1C3 (0.42) | HTR6AKR1C3AKR1C2 | |
| SCHEMBL6967437 | 0.83 | KMT2A (0.43) | HTR6ALDH1A1MAPTAKR1C3AKR1C2 | |
| SCHEMBL6977828 | 0.83 | HTR6 (0.44) | HTR6DRD2HTR2AHTR7MAPT | |
| SCHEMBL6977877 | 0.80 | HTR6 (0.46) | HTR6ALDH1A1MAPTPTGS2POLB | |
| SCHEMBL6965033 | 0.77 | AKR1C3 (0.44) | HTR6ALDH1A1NPSR1MAPTPTGS2 | |
| SCHEMBL6968051 | 0.76 | AKR1C3 (0.46) | HTR6ALDH1A1PTGS2AKR1C3AKR1C2 | |
| SCHEMBL6975974 | 0.74 | AKR1C3 (0.48) | HTR6NPSR1MAPTPTGS2RAB9A | |
| SCHEMBL1280692 | 0.67 | POLB (0.57) | ALDH1A1MAPTPOLBNPC1RAB9A | |
| SCHEMBL6970836 | 0.66 | PKM (0.40) | HTR6ALDH1A1MAPTPOLBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1077947-B1 | NOVEL 1,5 AND 3-O-SUBSTITUTED 1H-INDAZOLES WITH ANTI-ASTHMATIC, ANTI-ALLERGIC, ANTI-INFLAMMATORY, IMMUNO-MODULATING AND NEURO-PROTECTIVE EFFECT, METHOD FOR THE PRODUCTION AND USE THEREOF AS MEDICAMENTS | DRESDEN ARZNEIMITTEL (DE) | 2003-09-03 | — | — | EP | claimed |