Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA4 | P22748 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6967255 | 0.90 | AKR1C3 (0.42) | HTR6PKMCA12CA1CA2 | |
| SCHEMBL6967437 | 0.89 | KMT2A (0.43) | HTR6MAPTALDH1A1KDM4EKMT2A | |
| SCHEMBL6965033 | 0.84 | AKR1C3 (0.44) | HTR6MAPTALDH1A1PTGS2KDM4E | |
| SCHEMBL6968051 | 0.83 | AKR1C3 (0.46) | HTR6ALDH1A1PTGS2PKMMAPK1 | |
| SCHEMBL6977828 | 0.82 | HTR6 (0.44) | HTR6MAPTHTTRAB9A | |
| SCHEMBL6975974 | 0.81 | AKR1C3 (0.48) | HTR6MAPTPTGS2KDM4EKMT2A | |
| SCHEMBL6975772 | 0.80 | HTR6 (0.43) | HTR6MAPTALDH1A1PTGS2SMN1; SMN2 | |
| SCHEMBL6977822 | 0.78 | MAPT (0.49) | HTR6MAPTALDH1A1HTTHSD17B10 | |
| SCHEMBL6963364 | 0.78 | MEN1 (0.54) | HTR6MAPTALDH1A1KDM4EKMT2A | |
| SCHEMBL6975922 | 0.73 | NPC1 (0.43) | MAPTALDH1A1KMT2AMEN1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1077947-B1 | NOVEL 1,5 AND 3-O-SUBSTITUTED 1H-INDAZOLES WITH ANTI-ASTHMATIC, ANTI-ALLERGIC, ANTI-INFLAMMATORY, IMMUNO-MODULATING AND NEURO-PROTECTIVE EFFECT, METHOD FOR THE PRODUCTION AND USE THEREOF AS MEDICAMENTS | DRESDEN ARZNEIMITTEL (DE) | 2003-09-03 | — | — | EP | claimed |