SCHEMBL6975980

SCHEMBL6975980

Cc1nn(-c2c(Cl)cc(C(F)(F)F)cc2Cl)c(N)c1I

nearest known ligand 0.70

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
GABRB3 P28472 20/20 0.70
GABRP O00591 19/20 0.70
GABRD O14764 19/20 0.70
GABRA1 P14867 19/20 0.70
GABRB1 P18505 19/20 0.70
GABRG2 P18507 19/20 0.70
GABRA5 P31644 19/20 0.70
GABRA3 P34903 19/20 0.70
GABRA2 P47869 19/20 0.70
GABRB2 P47870 19/20 0.70
GABRA4 P48169 19/20 0.70
GABRE P78334 19/20 0.70
GABRA6 Q16445 19/20 0.70
GABRG1 Q8N1C3 19/20 0.70
GABRG3 Q99928 19/20 0.70
GABRQ Q9UN88 19/20 0.70

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6969042 0.85 GABRB3 (0.54) GABRB3GABRPGABRDGABRA1GABRB1
SCHEMBL1752339 0.84 GABRA2 (0.67) GABRB3GABRPGABRDGABRA1GABRB1
SCHEMBL10628680 0.84 GABRB3 (0.59) GABRB3GABRPGABRDGABRA1GABRB1
SCHEMBL6967743 0.83 GABRP (0.48) GABRB3GABRPGABRDGABRA1GABRB1
SCHEMBL6927512 0.82 GABRP (1.00) GABRB3GABRPGABRDGABRA1GABRB1
SCHEMBL7707207 0.82 GABRP (0.60) GABRB3GABRPGABRDGABRA1GABRB1
SCHEMBL27259715 0.81 GABRB3 (0.55) GABRB3GABRPGABRDGABRA1GABRB1
SCHEMBL7713492 0.81 GABRP (0.66) GABRB3GABRPGABRDGABRA1GABRB1
SCHEMBL9489922 0.80 GABRP (0.57) GABRB3GABRPGABRDGABRA1GABRB1
SCHEMBL2001805 0.80 GABRA2 (0.65) GABRB3GABRPGABRDGABRA1GABRB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6372774-B1 THESE COMPOUNDS POSSESS ARTHROPODICIDAL, PLANT NEMATOCIDAL, ANTHELMINTIC AND ANTI-PROTOZOAL PROPERTIES RHONE-POULENC AGRICULTURE LTD. (GB) 2002-04-16 US claimed
US-5916618-A PESTICIDE FOR MEDICATED FEEDSTUFF, DIETARY CONCENTRATE OR SUPPLEMENT RHONE-POULENC AGRICULTURE LTD. (GB) 1999-06-29 US claimed
CN-1159298-C Parasiticidal compound ������ҩ�����޹�˾ 2004-07-28 CN disclosed
EP-0946515-B1 PARASITICIDAL PYRAZOLES PFIZER LTD (GB) 2003-03-05 EP disclosed
US-6372774-B1 THESE COMPOUNDS POSSESS ARTHROPODICIDAL, PLANT NEMATOCIDAL, ANTHELMINTIC AND ANTI-PROTOZOAL PROPERTIES RHONE-POULENC AGRICULTURE LTD. (GB) 2002-04-16 US disclosed
EP-0871617-B1 PARASITICIDAL COMPOUNDS PFIZER (US) 2001-11-14 EP disclosed
US-6268509-B1 PESTICIDES PFIZER INC 2001-07-31 US disclosed
US-6255333-B1 HUMANS OR ANIMALS PFIZER INC. 2001-07-03 US disclosed
US-6075043-A Parasiticidal pyrazoles PFIZER INC. (US) 2000-06-13 US disclosed
EP-0738713-B1 Process for the preparation of pesticidal 1-(chloroaryl)heterocyclic compounds RHONE POULENC AGROCHIMIE (FR) 2000-02-09 EP disclosed
US-5916618-A PESTICIDE FOR MEDICATED FEEDSTUFF, DIETARY CONCENTRATE OR SUPPLEMENT RHONE-POULENC AGRICULTURE LTD. (GB) 1999-06-29 US disclosed
US-5714191-A PESTICIDES USED IN MEDICATED FEEDSTUFF, MINERAL SALT LICK OR EDIBLE BAIT RHONE-POULENC AGRICULTURE LTD. (GB) 1998-02-03 US disclosed
US-5608077-A INSECTICIDES, NEMATOCIDES, ANTHELMINTICS, ANTIPROTOZOA AGENTS RHONE-POULENC AGRICULTURE LTD. (GB) 1997-03-04 US disclosed
US-5547974-A INSECTICIDES, NEMATOCIDES, ANTHELMINTICS RHONE-POULENC AGRICULTURE LTD. (GB) 1996-08-20 US disclosed
CN-1025811-C Pesticidal method using N-phenyl pyrazoles MAY & BAKER LTD (GB) 1994-09-07 CN disclosed
EP-0579280-A1 Pesticidal method using N-phenylpyrazoles RHONE-POULENC AGROCHIMIE (FR) 1994-01-19 EP disclosed
US-5232940-A Controlling insects, plant nematodes, helminths, protozoa BASF AGRO B.V., ARNHEM (NL), WADENSWIL-BRANCH (CH) 1993-08-03 US disclosed
EP-0234119-A1 Pesticidal method using N-phenylpyrazoles RHONE-POULENC AGROCHIMIE (FR) 1987-09-02 EP disclosed
CN-86108643-A Insecticidal method using N-phenylpyrazoles 1987-07-29 CN disclosed
WO-1987003781-A1 PESTICIDAL METHOD USING N-PHENYLPYRAZOLES MAY & BAKER LIMITED (GB) 1987-07-02 WO disclosed