Sugi Predict

Sugi Predict / Compounds / SCHEMBL697604

SCHEMBL697604

SCHEMBL697604

Cc1cccc([C@H](C)c2nccn2C(=O)OCc2c(F)cccc2F)c1C

nearest known ligand 0.37

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
▸ GUCY1B2 O75343 10/20 0.37
▸ GUCY1A2 P33402 10/20 0.37
▸ GUCY1A1 Q02108 10/20 0.37
▸ GUCY1B1 Q02153 10/20 0.37
▸ KMT2A Q03164 3/20 0.35
▸ ALDH1A1 P00352 2/20 0.35
▸ ATM Q13315 1/20 0.35
▸ L3MBTL1 Q9Y468 1/20 0.35
▸ SCN5A Q14524 1/20 0.34
▸ SCN9A Q15858 1/20 0.34
▸ KDM4E B2RXH2 1/20 0.34
▸ TDP1 Q9NUW8 1/20 0.34
▸ GRIN2B Q13224 3/20 0.34
▸ MEN1 O00255 1/20 0.33
▸ NPC1 O15118 1/20 0.33
▸ RAB9A P51151 1/20 0.33
▸ GAA P10253 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL699227 0.94 GUCY1B2 (0.33) GUCY1B2GUCY1A2GUCY1A1GUCY1B1KMT2A
SCHEMBL697543 0.93 KMT2A (0.45) KMT2AALDH1A1ATML3MBTL1SCN5A
SCHEMBL697665 0.92 LMNA (0.33) GUCY1B2GUCY1A2GUCY1A1GUCY1B1KMT2A
SCHEMBL697841 0.92 MMP1 (0.33) GUCY1B2GUCY1A2GUCY1A1GUCY1B1KMT2A
SCHEMBL696420 0.90 LMNA (0.35) KMT2AALDH1A1L3MBTL1KDM4EMEN1
SCHEMBL702153 0.90 GRIN2B (0.39) GUCY1B2GUCY1A2GUCY1A1GUCY1B1KMT2A
SCHEMBL696474 0.88 LMNA (0.34) KMT2AALDH1A1KDM4EGRIN2BMEN1
SCHEMBL698376 0.88 ALDH1A1 (0.37) KMT2AALDH1A1ATML3MBTL1SCN5A
SCHEMBL697932 0.88 LMNA (0.34) KMT2AALDH1A1KDM4ETDP1GRIN2B
SCHEMBL696648 0.87 MAOB (0.34) KMT2AALDH1A1KDM4EMEN1NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2423199-A1 Substituted imidazoles and their use as pesticides Pfizer Limited (GB) 2012-02-29 — — EP disclosed
US-7825149-B2 Substituted imidazoles PFIZER LIMITED (GB) 2010-11-02 — — US disclosed
US-20090312326-A1 SUBSTITUTED IMIDAZOLES PFIZER LIMITED (GB) 2009-12-17 — — US disclosed
US-7592362-B2 Substituted imidazoles PFIZER LIMITED (GB) 2009-09-22 — — US disclosed
US-7547718-B2 Substituted imidazoles PFIZER LIMITED (GB) 2009-06-16 — — US disclosed
US-7544706-B2 Substituted imidazoles PFIZER LIMITED (GB) 2009-06-09 — — US disclosed
US-20080125473-A1 SUBSTITUTED IMIDAZOLES PFIZER LIMITED (GB) 2008-05-29 — — US disclosed
US-20080119536-A1 SUBSTITUTED IMIDAZOLES PFIZER LIMITED (GB) 2008-05-22 — — US disclosed
US-20070167506-A1 SUBSTITUTED IMIDAZOLES PFIZER INC. (US) 2007-07-19 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080125473-A1 SUBSTITUTED IMIDAZOLES ABL1, TYR, CYP3A4 GUCY1B2 614/4885GUCY1A2 1175/4885GUCY1A1 1626/4885
US-20090312326-A1 SUBSTITUTED IMIDAZOLES ABL1, TYR, CYP3A4 GUCY1B2 614/4885GUCY1A2 1175/4885GUCY1A1 1626/4885
US-20070167506-A1 SUBSTITUTED IMIDAZOLES ABL1, TYR, CYP3A4 GUCY1B2 614/4885GUCY1A2 1175/4885GUCY1A1 1626/4885
US-20080119536-A1 SUBSTITUTED IMIDAZOLES ABL1, TYR, CYP3A4 GUCY1B2 614/4885GUCY1A2 1175/4885GUCY1A1 1626/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.