Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GUCY1B2 | O75343 | 6/20 | 0.33 |
| ▸ | GUCY1A2 | P33402 | 6/20 | 0.33 |
| ▸ | GUCY1A1 | Q02108 | 6/20 | 0.33 |
| ▸ | GUCY1B1 | Q02153 | 6/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | FFAR1 | O14842 | 5/20 | 0.32 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.32 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.32 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL697604 | 0.94 | GUCY1B2 (0.37) | GUCY1B2GUCY1A2GUCY1A1GUCY1B1KMT2A | |
| SCHEMBL697665 | 0.92 | LMNA (0.33) | GUCY1B2GUCY1A2GUCY1A1GUCY1B1KMT2A | |
| SCHEMBL697841 | 0.92 | MMP1 (0.33) | GUCY1B2GUCY1A2GUCY1A1GUCY1B1KMT2A | |
| SCHEMBL703229 | 0.90 | P2RX7 (0.32) | KMT2AFFAR1GRIN2BLMNATP53 | |
| SCHEMBL697543 | 0.89 | KMT2A (0.45) | KMT2AALDH1A1ATML3MBTL1SCN5A | |
| SCHEMBL696420 | 0.89 | LMNA (0.35) | KMT2AALDH1A1L3MBTL1FFAR1LMNA | |
| SCHEMBL696648 | 0.87 | MAOB (0.34) | KMT2AALDH1A1FFAR1LMNAKDM4E | |
| SCHEMBL696474 | 0.87 | LMNA (0.34) | KMT2AALDH1A1FFAR1GRIN2BLMNA | |
| SCHEMBL698928 | 0.86 | MAOA (0.35) | KMT2AALDH1A1FFAR1LMNAKDM4E | |
| SCHEMBL702153 | 0.86 | GRIN2B (0.39) | GUCY1B2GUCY1A2GUCY1A1GUCY1B1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2423199-A1 | Substituted imidazoles and their use as pesticides | Pfizer Limited (GB) | 2012-02-29 | — | — | EP | disclosed |
| US-7825149-B2 | Substituted imidazoles | PFIZER LIMITED (GB) | 2010-11-02 | — | — | US | disclosed |
| US-20090312326-A1 | SUBSTITUTED IMIDAZOLES | PFIZER LIMITED (GB) | 2009-12-17 | — | — | US | disclosed |
| US-7592362-B2 | Substituted imidazoles | PFIZER LIMITED (GB) | 2009-09-22 | — | — | US | disclosed |
| US-7547718-B2 | Substituted imidazoles | PFIZER LIMITED (GB) | 2009-06-16 | — | — | US | disclosed |
| US-7544706-B2 | Substituted imidazoles | PFIZER LIMITED (GB) | 2009-06-09 | — | — | US | disclosed |
| US-20080125473-A1 | SUBSTITUTED IMIDAZOLES | PFIZER LIMITED (GB) | 2008-05-29 | — | — | US | disclosed |
| US-20080119536-A1 | SUBSTITUTED IMIDAZOLES | PFIZER LIMITED (GB) | 2008-05-22 | — | — | US | disclosed |
| US-20070167506-A1 | SUBSTITUTED IMIDAZOLES | PFIZER INC. (US) | 2007-07-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080125473-A1 | SUBSTITUTED IMIDAZOLES | ABL1, TYR, CYP3A4 | GUCY1B2 614/4885GUCY1A2 1175/4885GUCY1A1 1626/4885 |
| US-20090312326-A1 | SUBSTITUTED IMIDAZOLES | ABL1, TYR, CYP3A4 | GUCY1B2 614/4885GUCY1A2 1175/4885GUCY1A1 1626/4885 |
| US-20070167506-A1 | SUBSTITUTED IMIDAZOLES | ABL1, TYR, CYP3A4 | GUCY1B2 614/4885GUCY1A2 1175/4885GUCY1A1 1626/4885 |
| US-20080119536-A1 | SUBSTITUTED IMIDAZOLES | ABL1, TYR, CYP3A4 | GUCY1B2 614/4885GUCY1A2 1175/4885GUCY1A1 1626/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.