Sugi Predict

Sugi Predict / Compounds / SCHEMBL698376

SCHEMBL698376

SCHEMBL698376

Cc1cccc([C@H](C)c2nccn2C(=O)OCc2c(Cl)cccc2Cl)c1C

nearest known ligand 0.40

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 2/20 0.37
▸ KDM4E B2RXH2 1/20 0.37
▸ PTGER1 P34995 2/20 0.37
▸ PTGER4 P35408 2/20 0.37
▸ PTGER3 P43115 2/20 0.37
▸ PTGER2 P43116 2/20 0.37
▸ KMT2A Q03164 2/20 0.35
▸ ATM Q13315 1/20 0.35
▸ L3MBTL1 Q9Y468 1/20 0.35
▸ SCN5A Q14524 1/20 0.34
▸ SCN9A Q15858 1/20 0.34
▸ TDP1 Q9NUW8 2/20 0.34
▸ FFAR1 O14842 2/20 0.34
▸ GAA P10253 1/20 0.33
▸ KCNH2 Q12809 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL697543 0.93 KMT2A (0.45) ALDH1A1KMT2AATML3MBTL1SCN5A
SCHEMBL696420 0.90 LMNA (0.35) ALDH1A1KDM4EKMT2AL3MBTL1FFAR1
SCHEMBL696969 0.90 CASP3 (0.39) ALDH1A1PTGER3KMT2ASCN5ASCN9A
SCHEMBL698052 0.89 KCNH2 (0.36) ALDH1A1KMT2ASCN5ASCN9AFFAR1
SCHEMBL696474 0.88 LMNA (0.34) ALDH1A1KDM4EKMT2AFFAR1KCNH2
SCHEMBL697604 0.88 GUCY1B2 (0.37) ALDH1A1KDM4EKMT2AATML3MBTL1
SCHEMBL697841 0.88 MMP1 (0.33) ALDH1A1KMT2ATDP1FFAR1KCNH2
SCHEMBL697932 0.88 LMNA (0.34) ALDH1A1KDM4EKMT2ATDP1FFAR1
SCHEMBL699093 0.87 ALDH1A1 (0.40) ALDH1A1KDM4EKMT2AGAAKCNH2
SCHEMBL696991 0.87 L3MBTL1 (0.40) L3MBTL1FFAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2423199-A1 Substituted imidazoles and their use as pesticides Pfizer Limited (GB) 2012-02-29 — — EP disclosed
US-7825149-B2 Substituted imidazoles PFIZER LIMITED (GB) 2010-11-02 — — US disclosed
US-20090312326-A1 SUBSTITUTED IMIDAZOLES PFIZER LIMITED (GB) 2009-12-17 — — US disclosed
US-7592362-B2 Substituted imidazoles PFIZER LIMITED (GB) 2009-09-22 — — US disclosed
US-7547718-B2 Substituted imidazoles PFIZER LIMITED (GB) 2009-06-16 — — US disclosed
US-7544706-B2 Substituted imidazoles PFIZER LIMITED (GB) 2009-06-09 — — US disclosed
US-20080125473-A1 SUBSTITUTED IMIDAZOLES PFIZER LIMITED (GB) 2008-05-29 — — US disclosed
US-20080119536-A1 SUBSTITUTED IMIDAZOLES PFIZER LIMITED (GB) 2008-05-22 — — US disclosed
US-20070167506-A1 SUBSTITUTED IMIDAZOLES PFIZER INC. (US) 2007-07-19 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080125473-A1 SUBSTITUTED IMIDAZOLES ABL1, TYR, CYP3A4 ALDH1A1 617/4885KDM4E 574/4885PTGER1 3502/4885
US-20090312326-A1 SUBSTITUTED IMIDAZOLES ABL1, TYR, CYP3A4 ALDH1A1 617/4885KDM4E 574/4885PTGER1 3502/4885
US-20070167506-A1 SUBSTITUTED IMIDAZOLES ABL1, TYR, CYP3A4 ALDH1A1 617/4885KDM4E 574/4885PTGER1 3502/4885
US-20080119536-A1 SUBSTITUTED IMIDAZOLES ABL1, TYR, CYP3A4 ALDH1A1 617/4885KDM4E 574/4885PTGER1 3502/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.