Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.57 |
| ▸ | METAP2 | P50579 | 3/20 | 0.53 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | NAMPT | P43490 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6983238 | 0.87 | ALDH1A1 (0.57) | ALDH1A1KDM4EMETAP2LMNAMEN1 | |
| SCHEMBL1138968 | 0.87 | METAP2 (0.52) | ALDH1A1KDM4EMETAP2LMNAMEN1 | |
| SCHEMBL6983341 | 0.83 | METAP2 (0.56) | METAP2LMNAMEN1KMT2AMAPT | |
| SCHEMBL8716698 | 0.81 | POLB (0.65) | ALDH1A1KDM4ELMNAMEN1KMT2A | |
| SCHEMBL6972221 | 0.80 | ALDH1A1 (0.64) | ALDH1A1KDM4ELMNAMEN1KMT2A | |
| SCHEMBL14068762 | 0.79 | GHSR (0.61) | ALDH1A1KDM4ELMNAMEN1KMT2A | |
| SCHEMBL7571620 | 0.78 | POLB (0.68) | ALDH1A1MEN1KMT2A | |
| SCHEMBL12786357 | 0.77 | ALDH1A1 (0.54) | ALDH1A1LMNAMEN1KMT2AMAPT | |
| SCHEMBL25072986 | 0.77 | KDM4E (0.63) | ALDH1A1KDM4EMETAP2LMNAMEN1 | |
| SCHEMBL12786359 | 0.77 | PI4KB (0.51) | ALDH1A1KDM4ELMNAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1109560-B1 | COMPOUNDS USEFUL AS AICARFT INHIBITORS | AGOURON PHARMA (US) | 2003-08-27 | — | — | EP | disclosed |
| US-6525050-B1 | Inhibit the enzyme aminoimidazole carboxamide ribonucleotide formyl transferase; antiproliferative agents; antitumor, antiinflammatory, antipsoriatic, and/or immunosuppressive | AGOURON PHARMACEUTICALS, INC. | 2003-02-25 | — | — | US | disclosed |
| EP-1109560-A4 | COMPOUNDS USEFUL AS AICARFT INHIBITORS | AGOURON PHARMA (US) | 2002-04-17 | — | — | EP | disclosed |
| EP-1109560-A1 | COMPOUNDS USEFUL AS AICARFT INHIBITORS | AGOURON PHARMACEUTICALS, INC. (US) | 2001-06-27 | — | — | EP | disclosed |
| WO-2000013688-A1 | COMPOUNDS USEFUL AS AICARFT INHIBITORS | AGOURON PHARMACEUTICALS, INC. (US) | 2000-03-16 | — | — | WO | disclosed |