Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.65 |
| ▸ | HTT | P42858 | 1/20 | 0.64 |
| ▸ | MEN1 | O00255 | 3/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.60 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.60 |
| ▸ | NAMPT | P43490 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | GAA | P10253 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8752511 | 0.87 | POLB (0.63) | POLBHTTMEN1KMT2ALIMK2 | |
| SCHEMBL5459200 | 0.85 | ALDH1A1 (0.66) | POLBHTTMEN1KMT2ALIMK2 | |
| SCHEMBL1138968 | 0.83 | METAP2 (0.52) | POLBHTTMEN1KMT2ALIMK2 | |
| SCHEMBL3380247 | 0.83 | POLB (0.68) | POLBHTTMEN1KMT2AALDH1A1 | |
| SCHEMBL7572319 | 0.82 | POLB (0.68) | POLBHTTMEN1KMT2AALDH1A1 | |
| SCHEMBL789616 | 0.82 | KEAP1 (0.72) | POLBHTTMEN1KMT2AALDH1A1 | |
| SCHEMBL7571620 | 0.82 | POLB (0.68) | POLBHTTMEN1KMT2AALDH1A1 | |
| SCHEMBL6976064 | 0.81 | ALDH1A1 (0.60) | MEN1KMT2ANAMPTALDH1A1KDM4E | |
| SCHEMBL2246137 | 0.81 | POLB (0.70) | POLBHTTMEN1KMT2AALDH1A1 | |
| SCHEMBL7586724 | 0.81 | NPC1 (0.68) | POLBHTTMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5728835-A | HYPOTENSIVE AGENTS; ANTIISCHEMIC AGENTS | TOA EIYO, LTD. (JP) | 1998-03-17 | — | — | US | disclosed |
| EP-0661266-A1 | Substituted cyclic amine compounds as 5HT2 antagonists | TOA EIYO LTD. (JP) | 1995-07-05 | — | — | EP | disclosed |