Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.67 |
| ▸ | ACHE | P22303 | 2/20 | 0.66 |
| ▸ | BACE1 | P56817 | 2/20 | 0.66 |
| ▸ | POLB | P06746 | 2/20 | 0.63 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | MGLL | Q99685 | 1/20 | 0.57 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6973290 | 0.89 | EPHX1 (0.61) | ACHEEPHX2KMT2AALDH1A1LMNA | |
| SCHEMBL6970106 | 0.85 | ACHE (0.65) | GAAACHEBACE1POLBKMT2A | |
| SCHEMBL6981291 | 0.84 | MGLL (0.70) | EPHX2KMT2AHSD11B1MGLL | |
| SCHEMBL1720550 | 0.84 | POLB (0.89) | GAAACHEBACE1POLBKMT2A | |
| SCHEMBL6210853 | 0.84 | POLB (0.89) | GAAACHEBACE1POLBKMT2A | |
| SCHEMBL3097695 | 0.83 | SMN1; SMN2 (0.61) | GAAALDH1A1CYP2C9CYP2C19SMN1; SMN2 | |
| SCHEMBL18629798 | 0.82 | NPC1 (0.57) | KMT2AALDH1A1LMNAKDM4ECYP3A4 | |
| SCHEMBL11397786 | 0.81 | GAA (0.60) | GAAACHEBACE1POLBKMT2A | |
| SCHEMBL1162950 | 0.79 | ALDH1A1 (0.53) | EPHX2KMT2AALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL16002873 | 0.77 | POLB (0.68) | GAAACHEBACE1POLBEPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0892795-B1 | PIPERIDINYLPYRAMIDINE DERIVATIVES | SUMITOMO PHARMA (JP) | 2003-01-08 | — | — | EP | disclosed |
| EP-0892795-A1 | PIPERIDINYLPYRAMIDINE DERIVATIVES | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1999-01-27 | — | — | EP | disclosed |
| WO-1997038992-A1 | PIPERIDINYLPYRAMIDINE DERIVATIVES | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1997-10-23 | — | — | WO | disclosed |