Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 6/20 | 0.51 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.51 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.48 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.48 |
| ▸ | HTR2A | P28223 | 5/20 | 0.47 |
| ▸ | HTR7 | P34969 | 3/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.47 |
| ▸ | HTR1D | P28221 | 1/20 | 0.41 |
| ▸ | HTR1B | P28222 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 3/20 | 0.40 |
| ▸ | DRD1 | P21728 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | HTR6 | P50406 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6980903 | 0.91 | CTSS (0.40) | DRD2SLC6A4ADRA1DADRA1BHTR2A | |
| SCHEMBL6494165 | 0.90 | HTR1D (0.46) | DRD2SLC6A4ADRA1DADRA1BHTR2A | |
| SCHEMBL6493513 | 0.90 | HTR1D (0.46) | DRD2SLC6A4ADRA1DADRA1BHTR2A | |
| SCHEMBL8316466 | 0.88 | ADRA1D (0.57) | DRD2SLC6A4ADRA1DADRA1BHTR2A | |
| SCHEMBL6979112 | 0.87 | DRD2 (0.50) | DRD2SLC6A4ADRA1DADRA1BHTR2A | |
| SCHEMBL6984070 | 0.87 | DRD2 (0.35) | DRD2SLC6A4ADRA1DADRA1BHTR2A | |
| SCHEMBL6984714 | 0.87 | HTR6 (0.35) | DRD2SLC6A4ADRA1DADRA1BHTR2A | |
| SCHEMBL8311584 | 0.84 | ADRA1D (0.52) | DRD2SLC6A4ADRA1DADRA1BHTR2A | |
| SCHEMBL2877415 | 0.82 | SLC6A4 (0.58) | DRD2SLC6A4ADRA1DADRA1BHTR2A | |
| SCHEMBL6501558 | 0.78 | HTR1D (0.34) | HTR1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1131321-B1 | INDOLE DERIVATIVES AND THEIR USE AS SEROTONIN RECEPTOR LIGANDS | LILLY CO ELI (GB) | 2003-09-10 | — | — | EP | disclosed |
| US-6329366-B1 | HETEROCYCLIC, PIPERIDINE, INDOLE DERIVITIVES FOR TREATMENT OF NERVOUS SYSTEM DISORDERS AND SEROTONIN ANTAGONIST | ELI LILLY AND COMPANY LIMITED (GB) | 2001-12-11 | — | — | US | disclosed |