Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.34 |
| ▸ | CDK9 | P50750 | 2/20 | 0.34 |
| ▸ | GSK3B | P49841 | 5/20 | 0.33 |
| ▸ | GSK3A | P49840 | 1/20 | 0.33 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.33 |
| ▸ | CDK4 | P11802 | 1/20 | 0.33 |
| ▸ | CCND1 | P24385 | 1/20 | 0.33 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | PIM1 | P11309 | 1/20 | 0.33 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.33 |
| ▸ | PRKCA | P17252 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7010209 | 0.82 | PIM1 (0.37) | CCNT1CDK9GSK3BGSK3ACCNE2 | |
| SCHEMBL6983267 | 0.82 | CCNE2 (0.45) | CCNT1CDK9GSK3BCCNE2CDK4 | |
| SCHEMBL6983870 | 0.81 | L3MBTL1 (0.36) | ATMCCNT1CDK9GSK3BPIM1 | |
| SCHEMBL6980034 | 0.78 | CCNT1 (0.48) | CCNT1CDK9CDK2PIM1CAMK2D | |
| SCHEMBL6981894 | 0.78 | MAPT (0.37) | CCNT1CDK9GSK3BCDK2PIM1 | |
| SCHEMBL6981135 | 0.77 | ALDH1A1 (0.40) | CCNT1CDK9GSK3BCDK2CAMK2D | |
| SCHEMBL6985899 | 0.77 | MAPT (0.40) | CCNT1CDK9CDK2 | |
| SCHEMBL6973734 | 0.77 | CAMK2D (0.56) | CCNT1CDK9CDK2PIM1CAMK2D | |
| Hydrochloric Acid SCHEMBL6984367 | 0.76 | CAMK2D (0.55) | CCNT1CDK9CDK2PIM1CAMK2D | |
| SCHEMBL7013228 | 0.75 | PIM1 (0.42) | CCNT1CDK9GSK3BGSK3ACCNE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1095039-B1 | NEW PHARMACEUTICALLY ACTIVE COMPOUNDS | ASTRAZENECA AB (SE) | 2003-08-27 | — | — | EP | disclosed |
| US-6346625-B1 | ENZYME INHIBITORS FOR PROTEIN KINASES | ASTRAZENECA AB (SE) | 2002-02-12 | — | — | US | disclosed |