Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.36 |
| ▸ | LMNA | P02545 | 4/20 | 0.36 |
| ▸ | HTT | P42858 | 3/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.35 |
| ▸ | CDK9 | P50750 | 2/20 | 0.35 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | CNR1 | P21554 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | CA12 | O43570 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6980034 | 0.89 | CCNT1 (0.48) | MAPTSMN1; SMN2CCNT1CDK9CCNA2 | |
| SCHEMBL6981135 | 0.88 | ALDH1A1 (0.40) | MAPTSMN1; SMN2LMNAHTTTDP1 | |
| SCHEMBL6985899 | 0.88 | MAPT (0.40) | MAPTSMN1; SMN2LMNAHTTTDP1 | |
| SCHEMBL6979608 | 0.87 | CAMK2D (0.35) | SMN1; SMN2LMNAALDH1A1CREBBPKMT2A | |
| SCHEMBL6975872 | 0.78 | CNR1 (0.44) | MAPTCCNT1CDK9CCNA2CDK2 | |
| SCHEMBL6977867 | 0.78 | ATM (0.35) | CCNT1CDK9CDK2GSK3BCAMK2D | |
| SCHEMBL6980479 | 0.77 | CAMK2D (0.45) | CCNT1CDK9CCNA2CDK2CAMK2D | |
| SCHEMBL6977406 | 0.77 | CAMK2D (0.56) | CCNT1CDK9CAMK2DPIM1 | |
| SCHEMBL6975973 | 0.76 | CAMK2D (0.53) | CCNT1CDK9CCNA2CDK2CAMK2D | |
| SCHEMBL6981421 | 0.75 | ALDH1A1 (0.42) | MAPTSMN1; SMN2LMNAHTTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1095039-B1 | NEW PHARMACEUTICALLY ACTIVE COMPOUNDS | ASTRAZENECA AB (SE) | 2003-08-27 | — | — | EP | disclosed |
| US-6346625-B1 | ENZYME INHIBITORS FOR PROTEIN KINASES | ASTRAZENECA AB (SE) | 2002-02-12 | — | — | US | disclosed |