Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.36 |
| ▸ | CDK9 | P50750 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6985899 | 0.98 | MAPT (0.40) | ALDH1A1MAPTNPSR1MEN1KMT2A | |
| SCHEMBL6980034 | 0.89 | CCNT1 (0.48) | MAPTMEN1KMT2ACCNT1CDK9 | |
| SCHEMBL6981894 | 0.88 | MAPT (0.37) | ALDH1A1MAPTMEN1KMT2ACCNT1 | |
| SCHEMBL6981421 | 0.87 | ALDH1A1 (0.42) | ALDH1A1MAPTNPSR1MEN1KMT2A | |
| SCHEMBL7011646 | 0.86 | ALDH1A1 (0.39) | ALDH1A1MAPTNPSR1MEN1KMT2A | |
| SCHEMBL7009411 | 0.84 | ALDH1A1 (0.41) | ALDH1A1MAPTNPSR1MEN1KMT2A | |
| SCHEMBL6975872 | 0.77 | CNR1 (0.44) | MAPTCCNT1CDK9CCNA2CDK2 | |
| SCHEMBL6977867 | 0.77 | ATM (0.35) | CCNT1CDK9CDK2CAMK2DGSK3B | |
| SCHEMBL6980479 | 0.76 | CAMK2D (0.45) | CCNT1CDK9CCNA2CDK2CAMK2D | |
| SCHEMBL6977406 | 0.76 | CAMK2D (0.56) | CCNT1CDK9CAMK2D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1095039-B1 | NEW PHARMACEUTICALLY ACTIVE COMPOUNDS | ASTRAZENECA AB (SE) | 2003-08-27 | — | — | EP | disclosed |
| US-6346625-B1 | ENZYME INHIBITORS FOR PROTEIN KINASES | ASTRAZENECA AB (SE) | 2002-02-12 | — | — | US | disclosed |