Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | TDO2 | P48775 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | LTA4H | P09960 | 3/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20360672 | 0.76 | TDO2 (0.52) | ALDH1A1HSD17B10KDM4EMAPTGAA | |
| SCHEMBL5150567 | 0.76 | ALDH1A1 (0.47) | ALDH1A1HSD17B10KDM4EMAPTGAA | |
| SCHEMBL27921766 | 0.74 | KDM4E (0.42) | ALDH1A1HSD17B10KDM4EMAPTGAA | |
| SCHEMBL365802 | 0.74 | KDM4E (0.42) | ALDH1A1HSD17B10KDM4EMAPTGAA | |
| SCHEMBL147273 | 0.74 | KDM4E (0.42) | ALDH1A1HSD17B10KDM4EMAPTGAA | |
| SCHEMBL28041068 | 0.74 | KCNH2 (0.61) | ALDH1A1HSD17B10KDM4EMAPTGAA | |
| SCHEMBL16600073 | 0.74 | KCNH2 (0.55) | ALDH1A1HSD17B10KDM4EMAPTGAA | |
| SCHEMBL27803723 | 0.73 | MAPT (0.41) | ALDH1A1HSD17B10KDM4EMAPTGAA | |
| SCHEMBL6751146 | 0.73 | LTA4H (0.43) | ALDH1A1HSD17B10KDM4EMAPTGAA | |
| SCHEMBL1060974 | 0.73 | ADORA3 (0.56) | ALDH1A1HSD17B10KDM4EMAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1185528-A4 | INHIBITORS OF IL-12 PRODUCTION | SHIONOGI BIORES CORP (US) | 2003-03-26 | — | — | EP | disclosed |
| US-6384032-B1 | INTERLEUKIN INHIBITORS | SHIONOGI BIORESEARCH CORP. | 2002-05-07 | — | — | US | disclosed |
| EP-1185528-A1 | INHIBITORS OF IL-12 PRODUCTION | Shionogi Bioresearch Corporation (US) | 2002-03-13 | — | — | EP | disclosed |
| WO-2000078757-A1 | INHIBITORS OF IL-12 PRODUCTION | SHIONOGI BIORESEARCH CORP. (US) | 2000-12-28 | — | — | WO | disclosed |