SCHEMBL20360672

SCHEMBL20360672

Nc1c(-c2cccs2)ccc(-c2cccs2)c1N

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TDO2 P48775 1/20 0.52
ALDH1A1 P00352 5/20 0.47
KDM4E B2RXH2 4/20 0.47
HSD17B10 Q99714 3/20 0.47
MAPT P10636 3/20 0.47
NPC1 O15118 2/20 0.47
HPGD P15428 2/20 0.47
GAA P10253 2/20 0.47
RAB9A P51151 1/20 0.47
ATM Q13315 1/20 0.47
TSHR P16473 1/20 0.47
CYP3A4 P08684 2/20 0.47
CYP2C9 P11712 2/20 0.47
CYP1A2 P05177 1/20 0.47
CYP2D6 P10635 1/20 0.47
CYP2C19 P33261 1/20 0.47
KCNH2 Q12809 1/20 0.47
LTA4H P09960 3/20 0.46
EPHX2 P34913 1/20 0.45
ADORA2A P29274 3/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL904558 0.83 KCNH2 (0.47) TDO2ALDH1A1KDM4EHSD17B10MAPT
SCHEMBL15365507 0.82 TDO2 (0.46) TDO2ALDH1A1KDM4EHSD17B10MAPT
SCHEMBL16600073 0.78 KCNH2 (0.55) TDO2ALDH1A1KDM4EHSD17B10MAPT
SCHEMBL28852512 0.78 KCNH2 (0.46) TDO2ALDH1A1KDM4EHSD17B10MAPT
SCHEMBL2495572 0.78 KDM4E (0.50) TDO2ALDH1A1KDM4EHSD17B10MAPT
SCHEMBL9927346 0.77 LTA4H (0.47) TDO2ALDH1A1KDM4EHSD17B10MAPT
SCHEMBL29945128 0.77 LTA4H (0.47) TDO2ALDH1A1KDM4EHSD17B10MAPT
SCHEMBL20837438 0.77 HSD17B10 (0.48) TDO2ALDH1A1KDM4EHSD17B10MAPT
SCHEMBL6977933 0.76 ALDH1A1 (0.53) TDO2ALDH1A1KDM4EHSD17B10MAPT
SCHEMBL1060974 0.76 ADORA3 (0.56) TDO2ALDH1A1KDM4EHSD17B10MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-105111216-A Thiophene polycyclic organic semiconductor material synthesis based on pyrene BEIJING INST TECHNOLOGY 2015-12-02 CN claimed
US-20180198128-A1 FLUORINATED-POLYMER COATED ELECTRODES SOUTH DAKOTA BOARD OF REGENTS (US) 2018-07-12 US disclosed
US-20180198128-A1 FLUORINATED-POLYMER COATED ELECTRODES SOUTH DAKOTA BOARD OF REGENTS (US) 2018-07-12 US disclosed
US-20180198128-A1 FLUORINATED-POLYMER COATED ELECTRODES SOUTH DAKOTA BOARD OF REGENTS (US) 2018-07-12 US disclosed
CN-105111216-A Thiophene polycyclic organic semiconductor material synthesis based on pyrene BEIJING INST TECHNOLOGY 2015-12-02 CN disclosed