Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRCP | P42785 | 2/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | HTR7 | P34969 | 1/20 | 0.33 |
| ▸ | HTR6 | P50406 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL6969996 | 0.82 | KMT2A (0.46) | HRH3ALDH1A1MAPTKDM4EHTR2A | |
| SCHEMBL6978399 | 0.79 | ALDH1A1 (0.35) | PRCPALDH1A1MAPTKDM4ECNR1 | |
| SCHEMBL6970002 | 0.76 | HTR2A (0.34) | HRH3ALDH1A1MAPTSIGMAR1CACNA1G | |
| Hydrochloric Acid SCHEMBL6976894 | 0.76 | HRH3 (0.36) | HRH3ALDH1A1MAPTSIGMAR1KDM4E | |
| SCHEMBL6983235 | 0.75 | ALDH1A1 (0.39) | PRCPHRH3ALDH1A1MAPTKDM4E | |
| SCHEMBL16986122 | 0.73 | MPO (0.47) | HRH3ALDH1A1MAPTSIGMAR1KDM4E | |
| SCHEMBL16986138 | 0.72 | KDM4E (0.51) | ALDH1A1MAPTKDM4EHTR2AHTR2C | |
| Hydrochloric Acid SCHEMBL6982867 | 0.72 | KDM4E (0.44) | HRH3ALDH1A1MAPTKDM4ECNR1 | |
| Hydrochloric Acid SCHEMBL16986208 | 0.71 | MPO (0.45) | HRH3ALDH1A1MAPTSIGMAR1KDM4E | |
| Hydrochloric Acid SCHEMBL16986190 | 0.71 | KDM4E (0.50) | ALDH1A1MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1065205-B1 | HETEROAROMATIC DERIVATIVES | TAISHO PHARMACEUTICAL CO LTD (JP) | 2003-05-28 | — | — | EP | disclosed |
| EP-1207159-A1 | Aromaheterocyclic derivatives as dopamine D4 receptor antagonists | TAISHO PHARMACEUTICAL CO. LTD (JP) | 2002-05-22 | — | — | EP | disclosed |
| US-6291467-B1 | DOPAMINE D4 RECEPTOR ANTAGONIST COMPOUND HAVING AN ANTIPSYCHOTIC ACTION WITHOUT CAUSING EXTRAPYRAMIDAL DISEASES. | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2001-09-18 | — | — | US | disclosed |
| EP-1065205-A1 | HETEROAROMATIC DERIVATIVES | TAISHO PHARMACEUTICAL CO., LTD (JP) | 2001-01-03 | — | — | EP | disclosed |