Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 10/20 | 0.34 |
| ▸ | HTR2C | P28335 | 8/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | OGA | O60502 | 2/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | HTR7 | P34969 | 1/20 | 0.32 |
| ▸ | HTR6 | P50406 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.32 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.32 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.32 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | DRD2 | P14416 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6978399 | 0.80 | ALDH1A1 (0.35) | HTR2AHTR2CCNR1HTR7HTR6 | |
| Oxalic Acid SCHEMBL6969996 | 0.76 | KMT2A (0.46) | HTR2AALDH1A1MAPTHRH3KMT2A | |
| Oxalic Acid SCHEMBL6978397 | 0.76 | PRCP (0.37) | HTR2AHTR2CCNR1HTR7HTR6 | |
| Hydrochloric Acid SCHEMBL6976894 | 0.73 | HRH3 (0.36) | HTR2AHTR1ACNR1ALDH1A1MAPT | |
| SCHEMBL6983235 | 0.72 | ALDH1A1 (0.39) | HTR2AHTR1ACNR1ALDH1A1MAPT | |
| Hydrochloric Acid SCHEMBL6982867 | 0.70 | KDM4E (0.44) | CNR1ALDH1A1MAPTHRH3KCNH2 | |
| Hydrochloric Acid SCHEMBL6984682 | 0.68 | DRD2 (0.58) | HTR2AHTR2CHTR1AHTR7HRH3 | |
| SCHEMBL6975606 | 0.67 | HTR1A (0.38) | HTR2AHTR1AHTR7ALDH1A1MAPT | |
| SCHEMBL6975602 | 0.67 | HTR1A (0.38) | HTR2AHTR1AHTR7ALDH1A1MAPT | |
| SCHEMBL11037164 | 0.64 | KDM4E (0.43) | HTR2AHTR1AHTR7ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1065205-B1 | HETEROAROMATIC DERIVATIVES | TAISHO PHARMACEUTICAL CO LTD (JP) | 2003-05-28 | — | — | EP | disclosed |
| EP-1207159-A1 | Aromaheterocyclic derivatives as dopamine D4 receptor antagonists | TAISHO PHARMACEUTICAL CO. LTD (JP) | 2002-05-22 | — | — | EP | disclosed |
| US-6291467-B1 | DOPAMINE D4 RECEPTOR ANTAGONIST COMPOUND HAVING AN ANTIPSYCHOTIC ACTION WITHOUT CAUSING EXTRAPYRAMIDAL DISEASES. | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2001-09-18 | — | — | US | disclosed |