Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL6978397 | 0.82 | PRCP (0.37) | ALDH1A1MAPTKDM4EHRH3HTR2A | |
| SCHEMBL6970002 | 0.76 | HTR2A (0.34) | KMT2AALDH1A1MAPTHRH3HTR2A | |
| SCHEMBL6978399 | 0.74 | ALDH1A1 (0.35) | KMT2AMAPK1MEN1L3MBTL1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL6976894 | 0.74 | HRH3 (0.36) | KMT2AMAPK1MEN1LMNAL3MBTL1 | |
| SCHEMBL6983235 | 0.73 | ALDH1A1 (0.39) | L3MBTL1ALDH1A1MAPTPOLBGAA | |
| Hydrochloric Acid SCHEMBL6982867 | 0.70 | KDM4E (0.44) | L3MBTL1ALDH1A1MAPTPOLBGAA | |
| Hydrochloric Acid SCHEMBL6984682 | 0.68 | DRD2 (0.58) | KMT2AMEN1LMNAKDM4ESMN1; SMN2 | |
| SCHEMBL6975606 | 0.67 | HTR1A (0.38) | KMT2AALDH1A1MAPTHPGDHTR2A | |
| SCHEMBL6975602 | 0.67 | HTR1A (0.38) | KMT2AALDH1A1MAPTHPGDHTR2A | |
| SCHEMBL11037164 | 0.64 | KDM4E (0.43) | KMT2AMEN1LMNAL3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1065205-B1 | HETEROAROMATIC DERIVATIVES | TAISHO PHARMACEUTICAL CO LTD (JP) | 2003-05-28 | — | — | EP | disclosed |
| EP-1207159-A1 | Aromaheterocyclic derivatives as dopamine D4 receptor antagonists | TAISHO PHARMACEUTICAL CO. LTD (JP) | 2002-05-22 | — | — | EP | disclosed |
| US-6291467-B1 | DOPAMINE D4 RECEPTOR ANTAGONIST COMPOUND HAVING AN ANTIPSYCHOTIC ACTION WITHOUT CAUSING EXTRAPYRAMIDAL DISEASES. | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2001-09-18 | — | — | US | disclosed |