Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 10/20 | 0.40 |
| ▸ | F2 | P00734 | 1/20 | 0.39 |
| ▸ | SIRT2 | Q8IXJ6 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | RECQL | P46063 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | HIPK1 | Q86Z02 | 2/20 | 0.34 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | SIRT3 | Q9NTG7 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | CASK | O14936 | 1/20 | 0.34 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7674311 | 0.94 | F10 (0.42) | F10F2SIRT2MEN1TP53 | |
| Trifluoroacetic Acid SCHEMBL6981001 | 0.90 | TPSAB1 (0.41) | SIRT2PRKCBPIM1PRKCAPRKCH | |
| Trifluoroacetic Acid SCHEMBL6986763 | 0.86 | TPSAB1 (0.38) | SIRT2MEN1TSHRKMT2ASMN1; SMN2 | |
| SCHEMBL6974638 | 0.83 | PRKCB (0.40) | SIRT2MEN1TSHRKMT2ASMN1; SMN2 | |
| Trifluoroacetic Acid SCHEMBL6985520 | 0.82 | PIM1 (0.36) | TSHRSMN1; SMN2CCNT1PIM1CDK9 | |
| Trifluoroacetic Acid SCHEMBL6977475 | 0.82 | CAMK2D (0.48) | CCNT1PIM1RPS6KB1CDK9 | |
| Trifluoroacetic Acid SCHEMBL6982808 | 0.81 | CAMK2D (0.46) | SIRT2MEN1TP53CYP3A4MAPT | |
| Trifluoroacetic Acid SCHEMBL6979888 | 0.80 | PRKACA (0.41) | SIRT2MEN1TP53CYP3A4MAPT | |
| Trifluoroacetic Acid SCHEMBL6977279 | 0.80 | CAMK2D (0.41) | SIRT2MEN1TP53CYP3A4MAPT | |
| Trifluoroacetic Acid SCHEMBL6978145 | 0.79 | CCNT1 (0.39) | MEN1KMT2ATDP1CCNT1PIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1095039-B1 | NEW PHARMACEUTICALLY ACTIVE COMPOUNDS | ASTRAZENECA AB (SE) | 2003-08-27 | — | — | EP | disclosed |
| US-6346625-B1 | ENZYME INHIBITORS FOR PROTEIN KINASES | ASTRAZENECA AB (SE) | 2002-02-12 | — | — | US | disclosed |