Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | GALR3 | O60755 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | CCNT1 | O60563 | 3/20 | 0.35 |
| ▸ | CDK9 | P50750 | 3/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | CDK2 | P24941 | 2/20 | 0.34 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.33 |
| ▸ | CDK4 | P11802 | 1/20 | 0.33 |
| ▸ | CCND1 | P24385 | 1/20 | 0.33 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.33 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6984203 | 0.93 | PIM1 (0.41) | PIM1CAMK2DALDH1A1GALR3RAB9A | |
| Trifluoroacetic Acid SCHEMBL6986763 | 0.91 | TPSAB1 (0.38) | PIM1CAMK2DALDH1A1CCNT1CDK9 | |
| Trifluoroacetic Acid SCHEMBL6977475 | 0.89 | CAMK2D (0.48) | PIM1CAMK2DCCNT1CDK9CDK2 | |
| Trifluoroacetic Acid SCHEMBL6981001 | 0.89 | TPSAB1 (0.41) | PIM1CAMK2DTPSAB1 | |
| Trifluoroacetic Acid SCHEMBL6982808 | 0.88 | CAMK2D (0.46) | PIM1CAMK2DCCNT1CDK9TSHR | |
| Trifluoroacetic Acid SCHEMBL6977279 | 0.85 | CAMK2D (0.41) | PIM1CAMK2DCCNT1CDK9TSHR | |
| Trifluoroacetic Acid SCHEMBL6984346 | 0.84 | PRKCA (0.50) | PIM1CAMK2DCCNT1CDK9TSHR | |
| Trifluoroacetic Acid SCHEMBL6979888 | 0.84 | PRKACA (0.41) | PIM1CAMK2DCCNT1CDK9TSHR | |
| Trifluoroacetic Acid SCHEMBL6981733 | 0.84 | CAMK2D (0.42) | PIM1CAMK2DCCNT1CDK9TSHR | |
| Trifluoroacetic Acid SCHEMBL6978145 | 0.83 | CCNT1 (0.39) | PIM1CAMK2DCCNT1CDK9CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1095039-B1 | NEW PHARMACEUTICALLY ACTIVE COMPOUNDS | ASTRAZENECA AB (SE) | 2003-08-27 | — | — | EP | disclosed |
| US-6346625-B1 | ENZYME INHIBITORS FOR PROTEIN KINASES | ASTRAZENECA AB (SE) | 2002-02-12 | — | — | US | disclosed |
| EP-1095039-A2 | NEW PHARMACEUTICALLY ACTIVE COMPOUNDS | AstraZeneca AB (SE) | 2001-05-02 | — | — | EP | disclosed |
| WO-2000002877-A2 | NEW PHARMACEUTICALLY ACTIVE COMPOUNDS | ASTRAZENECA AB (SE) | 2000-01-20 | — | — | WO | disclosed |