Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 15/20 | 0.76 |
| ▸ | ACE2 | Q9BYF1 | 9/20 | 0.62 |
| ▸ | REN | P00797 | 1/20 | 0.57 |
| ▸ | LTA4H | P09960 | 2/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8268894 | 1.00 | ACE (0.76) | ACEACE2RENLTA4H | |
| SCHEMBL5970431 | 1.00 | ACE (0.76) | ACEACE2RENLTA4H | |
| SCHEMBL9477156 | 1.00 | ACE (0.76) | ACEACE2RENLTA4H | |
| SCHEMBL8261181 | 1.00 | ACE (0.76) | ACEACE2RENLTA4H | |
| SCHEMBL9574253 | 1.00 | ACE (0.76) | ACEACE2RENLTA4H | |
| SCHEMBL8256761 | 0.94 | ACE (0.69) | ACEACE2RENLTA4H | |
| SCHEMBL8265844 | 0.92 | ACE (0.65) | ACEACE2REN | |
| SCHEMBL13533686 | 0.92 | ACE (0.65) | ACEACE2REN | |
| SCHEMBL8257846 | 0.92 | ACE (0.65) | ACEACE2REN | |
| SCHEMBL31197026 | 0.91 | ACE (0.67) | ACEACE2RENLTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120040904-A1 | Boronate Medicaments for Preventing Thrombosis During Surgery | Trigen Holdings AG (GB) | 2012-02-16 | — | — | US | disclosed |
| US-20120040904-A1 | Boronate Medicaments for Preventing Thrombosis During Surgery | Trigen Holdings AG (GB) | 2012-02-16 | — | — | US | disclosed |
| US-20100035827-A1 | Multivalent metal salts of boronic acids | PAION DEUTSCHLAND GMBH (DE) | 2010-02-11 | — | — | US | disclosed |
| US-20100035827-A1 | Multivalent metal salts of boronic acids | PAION DEUTSCHLAND GMBH (DE) | 2010-02-11 | — | — | US | disclosed |
| US-20080166396-A1 | Boronate Medicaments Suitable for Short Duration Anticoagulation | TRIGEN HOLDINGS AG CLAREVILLE HOUSE (GB) | 2008-07-10 | — | — | US | disclosed |
| US-20080166396-A1 | Boronate Medicaments Suitable for Short Duration Anticoagulation | TRIGEN HOLDINGS AG CLAREVILLE HOUSE (GB) | 2008-07-10 | — | — | US | disclosed |
| US-7371729-B2 | Boronic acid salts useful in parenteral formulations | TRIGEN LIMITED (GB) | 2008-05-13 | — | — | US | disclosed |
| US-7371729-B2 | Boronic acid salts useful in parenteral formulations | TRIGEN LIMITED (GB) | 2008-05-13 | — | — | US | disclosed |
| US-20060084592-A1 | Peptide boronic acid inhibitors | TRIGEN LIMITED | 2006-04-20 | — | — | US | disclosed |
| US-20060084592-A1 | Peptide boronic acid inhibitors | TRIGEN LIMITED | 2006-04-20 | — | — | US | disclosed |
| US-5498779-A | ANTICOAGULANTS AND TREATMENT OF ASTHMA | MERRELL PHARMACEUTICALS INC. (US) | 1996-03-12 | — | — | US | disclosed |
| EP-0686642-A2 | Modified guanidino and amidino thrombin inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 1995-12-13 | — | — | EP | disclosed |
| US-5391705-A | Anticoagulants, treats thrombophlebitis, coronary thrombosis and asthma | MERRELL DOW PHARMACEUTICALS INC. (US) | 1995-02-21 | — | — | US | disclosed |
| EP-0601459-A2 | Sulfonamido heterocyclic thrombin inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 1994-06-15 | — | — | EP | disclosed |
| EP-0503203-A1 | Novel thrombin inhibitors | MERRELL DOW PHARMACEUTICALS INC. (US) | 1992-09-16 | — | — | EP | disclosed |
| EP-0504064-A1 | Novel thrombin inhibitors | MERRELL PHARMACEUTICALS INC. (US) | 1992-09-16 | — | — | EP | disclosed |
| EP-0185390-B1 | TRIPEPTIDYL-ARGININALDEHYDE, PROCESS FOR ITS PREPARATION AND MEDICAMENTS THEREOF, AS WELL AS N-(MONOALKYL) AND N,N-DI-(ALKYL)-XXX-L-PROLINE DIPEPTIDE | RICHTER GEDEON VEGYESZETI GYAR R.T. (HU) | 1991-10-02 | — | — | EP | disclosed |
| US-4703036-A | ANTICOAGULANTS | RICHTER GEDEON VEGYESZETI GYAR RT (HU) | 1987-10-27 | — | — | US | disclosed |
| EP-0185390-A2 | Tripeptidyl-argininaldehyde, process for its preparation and medicaments thereof, as well as N-(monoalkyl) and N,N-di-(alkyl)-Xxx-L-proline dipeptide | RICHTER GEDEON VEGYESZETI GYAR R.T. (HU) | 1986-06-25 | — | — | EP | disclosed |
| US-4346078-A | Novel anticoagulant agmatine derivatives and process for the preparation thereof | RICHTER GEDEON VEGYESZETI GYAR RT. (HU) | 1982-08-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060084592-A1 | Peptide boronic acid inhibitors | BMX, YBX1, HAX1 | ACE 220/4885ACE2 817/4885REN 100/4885 |
| US-20120040904-A1 | Boronate Medicaments for Preventing Thrombosis During Surgery | F9, FGB, TFPI | ACE 2313/4885ACE2 2592/4885REN 2617/4885 |
| US-20100035827-A1 | Multivalent metal salts of boronic acids | BTD, SLC5A6, BPGM | ACE 85/4885ACE2 514/4885REN 958/4885 |
| US-20080166396-A1 | Boronate Medicaments Suitable for Short Duration Anticoagulation | F2, HABP2, BDKRB1 | ACE 495/4885ACE2 986/4885REN 1409/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.