Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNE1 | P15382 | 3/20 | 0.34 |
| ▸ | KCNQ1 | P51787 | 3/20 | 0.34 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.32 |
| ▸ | ATP4A | P20648 | 1/20 | 0.31 |
| ▸ | ATP4B | P51164 | 1/20 | 0.31 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | BCHE | P06276 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.31 |
| ▸ | IDO1 | P14902 | 1/20 | 0.30 |
| ▸ | LTB4R | Q15722 | 2/20 | 0.30 |
| ▸ | LTB4R2 | Q9NPC1 | 2/20 | 0.30 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6966585 | 0.90 | KCNE1 (0.32) | KCNE1KCNQ1LMNAGAABCHE | |
| SCHEMBL8487108 | 0.90 | KCNE1 (0.34) | KCNE1KCNQ1PTPN1LMNAGAA | |
| SCHEMBL8867575 | 0.85 | KCNE1 (0.38) | KCNE1KCNQ1PTPN1LMNAGAA | |
| SCHEMBL8868743 | 0.85 | KCNE1 (0.38) | KCNE1KCNQ1PTPN1LMNAGAA | |
| SCHEMBL979035 | 0.85 | KCNE1 (0.38) | KCNE1KCNQ1PTPN1LMNAGAA | |
| SCHEMBL6981132 | 0.84 | RAB9A (0.39) | KCNE1KCNQ1GAAMAPTL3MBTL1 | |
| SCHEMBL6968430 | 0.82 | MCHR1 (0.37) | KCNE1KCNQ1 | |
| SCHEMBL6968820 | 0.81 | KCNH2 (0.44) | LMNAMAPTMAPK1 | |
| SCHEMBL6969588 | 0.79 | PPARG (0.47) | MAPTTDP1 | |
| SCHEMBL6976223 | 0.79 | PPARG (0.37) | LMNAL3MBTL1LTB4RLTB4R2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0801063-B1 | Thiazolidinedione derivatives having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them | REDDYS LAB LTD DR (IN) | 2003-01-15 | — | — | EP | disclosed |
| US-5925656-A | CONTAINING A 2,4-DIOXOTRIAZOLIDINE RING | DR. REDDY'S RESEARCH FOUNDATION (IN) | 1999-07-20 | — | — | US | disclosed |
| EP-0801063-A1 | Thiazolidinedione derivatives having antidiabetic, hypolipidaemic antihypertensive properties, process for their preparation and pharmaceutical compositions containing them | DR. REDDY'S RESEARCH FOUNDATION (IN) | 1997-10-15 | — | — | EP | disclosed |