Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | MCHR1 | Q99705 | 4/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.35 |
| ▸ | LTA4H | P09960 | 1/20 | 0.33 |
| ▸ | KCNE1 | P15382 | 3/20 | 0.33 |
| ▸ | KCNQ1 | P51787 | 3/20 | 0.33 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.33 |
| ▸ | F2 | P00734 | 1/20 | 0.31 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6968430 | 0.89 | MCHR1 (0.37) | MAOBMCHR1KCNH2TSHRADRA1A | |
| SCHEMBL6968820 | 0.88 | KCNH2 (0.44) | MAPTMAOBSMN1; SMN2MCHR1KCNH2 | |
| SCHEMBL6980167 | 0.84 | KCNE1 (0.34) | GAAMAPTL3MBTL1KCNE1KCNQ1 | |
| SCHEMBL6966585 | 0.84 | KCNE1 (0.32) | GAAMAPTL3MBTL1KCNE1KCNQ1 | |
| SCHEMBL8487108 | 0.84 | KCNE1 (0.34) | GAAMAPTMAOAMAOBL3MBTL1 | |
| SCHEMBL6969588 | 0.83 | PPARG (0.47) | MAPTTSHR | |
| SCHEMBL6976223 | 0.83 | PPARG (0.37) | MAOBL3MBTL1ADRA1ALTA4HADRA1B | |
| SCHEMBL6963373 | 0.83 | HPGD (0.51) | MAOAMAOB | |
| SCHEMBL6963266 | 0.83 | HPGD (0.51) | MAOAMAOB | |
| SCHEMBL6980438 | 0.76 | MAPT (0.38) | RAB9AGAAMAPTMAOAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0801063-B1 | Thiazolidinedione derivatives having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them | REDDYS LAB LTD DR (IN) | 2003-01-15 | — | — | EP | disclosed |
| EP-0801063-A1 | Thiazolidinedione derivatives having antidiabetic, hypolipidaemic antihypertensive properties, process for their preparation and pharmaceutical compositions containing them | DR. REDDY'S RESEARCH FOUNDATION (IN) | 1997-10-15 | — | — | EP | disclosed |