Sugi Predict

Sugi Predict / Compounds / SCHEMBL698052

SCHEMBL698052

SCHEMBL698052

Cc1cccc([C@H](C)c2nccn2C(=O)OCc2cccc(Cl)c2Cl)c1C

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KCNH2 Q12809 1/20 0.36
▸ FFAR1 O14842 3/20 0.34
▸ P2RX7 Q99572 1/20 0.33
▸ GRIN2B Q13224 1/20 0.32
▸ ADA P00813 1/20 0.32
▸ CASP3 P42574 2/20 0.32
▸ SENP8 Q96LD8 2/20 0.32
▸ SENP7 Q9BQF6 2/20 0.32
▸ SENP6 Q9GZR1 2/20 0.32
▸ MEN1 O00255 2/20 0.32
▸ KMT2A Q03164 2/20 0.32
▸ RAB9A P51151 2/20 0.32
▸ IDO1 P14902 2/20 0.32
▸ LMNA P02545 1/20 0.32
▸ ALDH1A1 P00352 1/20 0.32
▸ HTT P42858 1/20 0.32
▸ PTGDR2 Q9Y5Y4 1/20 0.32
▸ TP53 P04637 1/20 0.32
▸ MAPT P10636 1/20 0.32
▸ CTSA P10619 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL696969 0.93 CASP3 (0.39) FFAR1GRIN2BCASP3SENP8SENP7
SCHEMBL698376 0.89 ALDH1A1 (0.37) KCNH2FFAR1KMT2AALDH1A1SCN5A
SCHEMBL698176 0.89 GRIN2B (0.41) FFAR1GRIN2BMEN1KMT2ALMNA
SCHEMBL3533877 0.87 SCN5A (0.40) FFAR1MEN1KMT2ARAB9AIDO1
SCHEMBL697306 0.85 MAPT (0.41) MEN1KMT2ARAB9AALDH1A1PTGDR2
SCHEMBL702153 0.85 GRIN2B (0.39) GRIN2BMEN1KMT2ARAB9ALMNA
SCHEMBL700359 0.85 L3MBTL1 (0.45) P2RX7MEN1KMT2AALDH1A1HTT
SCHEMBL697709 0.85 LMNA (0.34) KCNH2FFAR1GRIN2BMEN1KMT2A
SCHEMBL697543 0.85 KMT2A (0.45) MEN1KMT2ALMNAALDH1A1MAPT
SCHEMBL698766 0.84 KMT2A (0.40) GRIN2BMEN1KMT2AALDH1A1TP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2423199-A1 Substituted imidazoles and their use as pesticides Pfizer Limited (GB) 2012-02-29 — — EP disclosed
US-7825149-B2 Substituted imidazoles PFIZER LIMITED (GB) 2010-11-02 — — US disclosed
US-20090312326-A1 SUBSTITUTED IMIDAZOLES PFIZER LIMITED (GB) 2009-12-17 — — US disclosed
US-7592362-B2 Substituted imidazoles PFIZER LIMITED (GB) 2009-09-22 — — US disclosed
US-7547718-B2 Substituted imidazoles PFIZER LIMITED (GB) 2009-06-16 — — US disclosed
US-7544706-B2 Substituted imidazoles PFIZER LIMITED (GB) 2009-06-09 — — US disclosed
US-20080125473-A1 SUBSTITUTED IMIDAZOLES PFIZER LIMITED (GB) 2008-05-29 — — US disclosed
US-20080119536-A1 SUBSTITUTED IMIDAZOLES PFIZER LIMITED (GB) 2008-05-22 — — US disclosed
US-20070167506-A1 SUBSTITUTED IMIDAZOLES PFIZER INC. (US) 2007-07-19 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080125473-A1 SUBSTITUTED IMIDAZOLES ABL1, TYR, CYP3A4 KCNH2 277/4885FFAR1 4603/4885P2RX7 671/4885
US-20090312326-A1 SUBSTITUTED IMIDAZOLES ABL1, TYR, CYP3A4 KCNH2 277/4885FFAR1 4603/4885P2RX7 671/4885
US-20070167506-A1 SUBSTITUTED IMIDAZOLES ABL1, TYR, CYP3A4 KCNH2 277/4885FFAR1 4603/4885P2RX7 671/4885
US-20080119536-A1 SUBSTITUTED IMIDAZOLES ABL1, TYR, CYP3A4 KCNH2 277/4885FFAR1 4603/4885P2RX7 671/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.