Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKACA | P17612 | 5/20 | 0.39 |
| ▸ | PRKACG | P22612 | 5/20 | 0.39 |
| ▸ | PRKACB | P22694 | 5/20 | 0.39 |
| ▸ | CAMK2D | Q13557 | 2/20 | 0.39 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | CDK4 | P11802 | 3/20 | 0.35 |
| ▸ | CCND1 | P24385 | 3/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.34 |
| ▸ | PDE4A | P27815 | 2/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL6984982 | 0.93 | TPSAB1 (0.40) | PRKACAPRKACGPRKACBCAMK2DRPS6KB1 | |
| SCHEMBL6974638 | 0.85 | PRKCB (0.40) | CAMK2DMEN1KMT2ASMN1; SMN2TDP1 | |
| SCHEMBL7008945 | 0.85 | PRKACA (0.43) | PRKACAPRKACGPRKACBCAMK2DRPS6KB1 | |
| SCHEMBL6980064 | 0.85 | PRKACA (0.52) | PRKACAPRKACGPRKACBCAMK2DRPS6KB1 | |
| SCHEMBL6981937 | 0.84 | CAMK2D (0.56) | PRKACAPRKACGPRKACBCAMK2DRPS6KB1 | |
| SCHEMBL7811931 | 0.84 | CAMK2D (0.40) | CAMK2DRPS6KB1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL6979319 | 0.83 | CAMK2D (0.52) | PRKACAPRKACGPRKACBCAMK2DRPS6KB1 | |
| SCHEMBL7835441 | 0.81 | PRKACA (0.44) | PRKACAPRKACGPRKACBCAMK2DRPS6KB1 | |
| SCHEMBL6982388 | 0.81 | PRKACA (0.56) | PRKACAPRKACGPRKACBCAMK2DRPS6KB1 | |
| Trifluoroacetic Acid SCHEMBL6981001 | 0.80 | TPSAB1 (0.41) | CAMK2DSIRT2PRKCBPRKCAPIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1095039-B1 | NEW PHARMACEUTICALLY ACTIVE COMPOUNDS | ASTRAZENECA AB (SE) | 2003-08-27 | — | — | EP | claimed |
| US-6346625-B1 | ENZYME INHIBITORS FOR PROTEIN KINASES | ASTRAZENECA AB (SE) | 2002-02-12 | — | — | US | claimed |
| EP-1095039-B1 | NEW PHARMACEUTICALLY ACTIVE COMPOUNDS | ASTRAZENECA AB (SE) | 2003-08-27 | — | — | EP | disclosed |
| US-6346625-B1 | ENZYME INHIBITORS FOR PROTEIN KINASES | ASTRAZENECA AB (SE) | 2002-02-12 | — | — | US | disclosed |