Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.40 |
| ▸ | CCR5 | P51681 | 6/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.36 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.36 |
| ▸ | CCR3 | P51677 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6981926 | 0.97 | HRH3 (0.39) | HRH3CCR5ACHESLC18A3CYP2D6 | |
| SCHEMBL6976496 | 0.94 | CARM1 (0.42) | ACHECARM1PRMT6MAOAMAOB | |
| SCHEMBL6979705 | 0.88 | PRMT6 (0.43) | CARM1PRMT6CCR3SIGMAR1 | |
| SCHEMBL8578227 | 0.86 | SIGMAR1 (0.46) | CCR3SIGMAR1 | |
| SCHEMBL6985084 | 0.86 | AGTR2 (0.36) | HRH3CARM1PRMT6SIGMAR1OPRK1 | |
| Hydrochloric Acid SCHEMBL6984004 | 0.85 | SIGMAR1 (0.45) | CCR3SIGMAR1 | |
| Hydrochloric Acid SCHEMBL6982193 | 0.84 | SIGMAR1 (0.45) | CCR3SIGMAR1 | |
| SCHEMBL6981065 | 0.84 | SIGMAR1 (0.41) | ACHESIGMAR1 | |
| SCHEMBL6981562 | 0.82 | DRD2 (0.43) | SLC18A3CYP2D6CARM1PRMT6SIGMAR1 | |
| SCHEMBL7811043 | 0.82 | DRD2 (0.43) | SLC18A3CYP2D6CARM1PRMT6SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0923575-B1 | CYCLIC ETHER COMPOUNDS AS SODIUM CHANNEL MODULATORS | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2003-03-12 | — | — | EP | disclosed |
| US-6172085-B1 | CENTRAL NERVOUS SYSTEM AND PSYCHOLOGICAL DISORDERS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2001-01-09 | — | — | US | disclosed |