Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 7/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 2/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | NOS3 | P29474 | 1/20 | 0.37 |
| ▸ | NOS1 | P29475 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8578227 | 0.94 | SIGMAR1 (0.46) | SIGMAR1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL6984004 | 0.93 | SIGMAR1 (0.45) | SIGMAR1ALDH1A1MEN1KMT2ANPSR1 | |
| Hydrochloric Acid SCHEMBL6982193 | 0.92 | SIGMAR1 (0.45) | SIGMAR1 | |
| SCHEMBL6985365 | 0.89 | LMNA (0.42) | SIGMAR1ALDH1A1ACHESMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL6979044 | 0.88 | LMNA (0.41) | SIGMAR1ALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL6976496 | 0.85 | CARM1 (0.42) | ACHEKCNH2 | |
| SCHEMBL6977655 | 0.85 | TSHR (0.47) | SIGMAR1ALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL6983488 | 0.84 | DRD2 (0.41) | SIGMAR1ALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL6981074 | 0.84 | HRH3 (0.40) | SIGMAR1ACHE | |
| SCHEMBL6974100 | 0.83 | NPC1 (0.48) | SIGMAR1ALDH1A1MAPTNPSR1SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0923575-B1 | CYCLIC ETHER COMPOUNDS AS SODIUM CHANNEL MODULATORS | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2003-03-12 | — | — | EP | disclosed |
| US-6172085-B1 | CENTRAL NERVOUS SYSTEM AND PSYCHOLOGICAL DISORDERS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2001-01-09 | — | — | US | disclosed |