Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.66 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.66 |
| ▸ | TSHR | P16473 | 5/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | CES2 | O00748 | 1/20 | 0.45 |
| ▸ | CES1 | P23141 | 1/20 | 0.45 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | F2 | P00734 | 1/20 | 0.44 |
| ▸ | PLAU | P00749 | 1/20 | 0.44 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.44 |
| ▸ | ELANE | P08246 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29758194 | 0.90 | TSHR (0.61) | ALDH1A1TDP1TSHRLMNAALOX15 | |
| SCHEMBL127723 | 0.90 | TSHR (0.61) | ALDH1A1TDP1TSHRLMNAALOX15 | |
| Hydrochloric Acid SCHEMBL28382242 | 0.88 | TSHR (0.59) | ALDH1A1TDP1TSHRLMNAALOX15 | |
| Boric Acid SCHEMBL28213242 | 0.84 | ALDH1A1 (0.85) | ALDH1A1TDP1TSHRLMNAALOX15 | |
| Phosphoric Acid SCHEMBL28445592 | 0.83 | TSHR (0.53) | ALDH1A1TDP1TSHRLMNAALOX15 | |
| SCHEMBL6981184 | 0.83 | ALDH1A1 (0.55) | ALDH1A1TDP1TSHRLMNAALOX15 | |
| SCHEMBL1668771 | 0.81 | TSHR (0.47) | ALDH1A1TDP1TSHRLMNAALOX15 | |
| Cadaverine Tartrate SCHEMBL28355308 | 0.81 | TP53 (0.49) | ALDH1A1TDP1TSHRLMNAALOX15 | |
| SCHEMBL249999 | 0.80 | ALDH1A1 (1.00) | ALDH1A1TDP1TSHRLMNAALOX15 | |
| SCHEMBL11815 | 0.80 | ENPP2 (0.56) | ALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1244446-A4 | THROMBOPOIETIN MIMETICS | SMITHKLINE BEECHAM CORP (US) | 2003-01-08 | — | — | EP | disclosed |
| EP-1244446-A1 | THROMBOPOIETIN MIMETICS | SmithKline Beecham Corporation (US) | 2002-10-02 | — | — | EP | disclosed |
| WO-2001039773-A1 | THROMBOPOIETIN MIMETICS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-06-07 | — | — | WO | disclosed |