Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNT1 | O60563 | 3/20 | 0.42 |
| ▸ | CDK9 | P50750 | 3/20 | 0.42 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.41 |
| ▸ | CDK2 | P24941 | 2/20 | 0.41 |
| ▸ | CNR2 | P34972 | 8/20 | 0.38 |
| ▸ | CNR1 | P21554 | 2/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | MGAM | O43451 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | SI | P14410 | 2/20 | 0.36 |
| ▸ | MGAM2 | Q2M2H8 | 2/20 | 0.36 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6979460 | 0.89 | CAMK2D (0.42) | CCNT1CDK9CCNA2CDK2CNR2 | |
| SCHEMBL6978208 | 0.77 | CNR1 (0.40) | CCNT1CDK9CCNA2CDK2CNR2 | |
| SCHEMBL6980500 | 0.76 | CCNT1 (0.41) | CCNT1CDK9CCNA2CDK2CAMK2D | |
| SCHEMBL6980479 | 0.74 | CAMK2D (0.45) | CCNT1CDK9CCNA2CDK2CAMK2D | |
| SCHEMBL6985899 | 0.73 | MAPT (0.40) | CCNT1CDK9CCNA2CDK2CNR2 | |
| SCHEMBL6981135 | 0.71 | ALDH1A1 (0.40) | CCNT1CDK9CCNA2CDK2CNR1 | |
| Dimethylamine SCHEMBL6976140 | 0.69 | CCNT1 (0.41) | CCNT1CDK9CCNA2CDK2MGAM | |
| Trifluoroacetic Acid SCHEMBL6985258 | 0.69 | CAMK2D (0.39) | CCNT1CDK9CCNA2CDK2CNR2 | |
| SCHEMBL7815250 | 0.66 | MAPT (0.54) | CNR2GLAMAPTMAPK1GAA | |
| SCHEMBL6979590 | 0.66 | CCNT1 (0.42) | CCNT1CDK9CCNA2CDK2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1095039-B1 | NEW PHARMACEUTICALLY ACTIVE COMPOUNDS | ASTRAZENECA AB (SE) | 2003-08-27 | — | — | EP | disclosed |
| US-6346625-B1 | ENZYME INHIBITORS FOR PROTEIN KINASES | ASTRAZENECA AB (SE) | 2002-02-12 | — | — | US | disclosed |
| EP-1095039-A2 | NEW PHARMACEUTICALLY ACTIVE COMPOUNDS | AstraZeneca AB (SE) | 2001-05-02 | — | — | EP | disclosed |
| WO-2000002877-A2 | NEW PHARMACEUTICALLY ACTIVE COMPOUNDS | ASTRAZENECA AB (SE) | 2000-01-20 | — | — | WO | disclosed |