Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNT1 | O60563 | 3/20 | 0.41 |
| ▸ | CDK9 | P50750 | 3/20 | 0.41 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | PRKCA | P17252 | 2/20 | 0.35 |
| ▸ | PRKCG | P05129 | 1/20 | 0.35 |
| ▸ | PRKCB | P05771 | 1/20 | 0.35 |
| ▸ | PRKCH | P24723 | 1/20 | 0.35 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.35 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.35 |
| ▸ | CAMK2D | Q13557 | 3/20 | 0.34 |
| ▸ | PIM1 | P11309 | 2/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | PRKACA | P17612 | 1/20 | 0.33 |
| ▸ | PRKACG | P22612 | 1/20 | 0.33 |
| ▸ | PRKACB | P22694 | 1/20 | 0.33 |
| ▸ | IDH1 | O75874 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7014052 | 0.80 | CCNT1 (0.41) | CCNT1CDK9CCNA2CDK2PRKCA | |
| SCHEMBL6983870 | 0.79 | L3MBTL1 (0.36) | CCNT1CDK9PRKCAPRKCGPRKCB | |
| SCHEMBL6982735 | 0.79 | CCNT1 (0.41) | CCNT1CDK9CDK2PRKCAPRKCG | |
| SCHEMBL6981336 | 0.76 | CCNT1 (0.42) | CCNT1CDK9CCNA2CDK2CAMK2D | |
| SCHEMBL6981135 | 0.70 | ALDH1A1 (0.40) | CCNT1CDK9CCNA2CDK2CAMK2D | |
| SCHEMBL6985899 | 0.68 | MAPT (0.40) | CCNT1CDK9CCNA2CDK2 | |
| SCHEMBL6979460 | 0.66 | CAMK2D (0.42) | CCNT1CDK9CCNA2CDK2CAMK2D | |
| SCHEMBL6973734 | 0.66 | CAMK2D (0.56) | CCNT1CDK9CCNA2CDK2PRKCA | |
| SCHEMBL6978208 | 0.65 | CNR1 (0.40) | CCNT1CDK9CCNA2CDK2 | |
| SCHEMBL6981421 | 0.65 | ALDH1A1 (0.42) | CAMK2DPIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1095039-B1 | NEW PHARMACEUTICALLY ACTIVE COMPOUNDS | ASTRAZENECA AB (SE) | 2003-08-27 | — | — | EP | disclosed |
| US-6346625-B1 | ENZYME INHIBITORS FOR PROTEIN KINASES | ASTRAZENECA AB (SE) | 2002-02-12 | — | — | US | disclosed |
| EP-1095039-A2 | NEW PHARMACEUTICALLY ACTIVE COMPOUNDS | AstraZeneca AB (SE) | 2001-05-02 | — | — | EP | disclosed |
| WO-2000002877-A2 | NEW PHARMACEUTICALLY ACTIVE COMPOUNDS | ASTRAZENECA AB (SE) | 2000-01-20 | — | — | WO | disclosed |