Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BMP1 | P13497 | 4/20 | 0.38 |
| ▸ | MMP2 | P08253 | 2/20 | 0.38 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.34 |
| ▸ | REN | P00797 | 6/20 | 0.33 |
| ▸ | PSMB10 | P40306 | 1/20 | 0.33 |
| ▸ | PSMB2 | P49721 | 1/20 | 0.33 |
| ▸ | MMP1 | P03956 | 1/20 | 0.32 |
| ▸ | MMP13 | P45452 | 1/20 | 0.32 |
| ▸ | MMP3 | P08254 | 1/20 | 0.32 |
| ▸ | APP | P05067 | 1/20 | 0.31 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.31 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.31 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.31 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.31 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.31 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.31 |
| ▸ | KLK7 | P49862 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6986124 | 0.89 | CTSS (0.36) | BMP1MMP2REN | |
| SCHEMBL6982041 | 0.88 | BMP1 (0.39) | BMP1MMP2PSMB5REN | |
| SCHEMBL6981390 | 0.86 | BMP1 (0.37) | BMP1MMP2RENAPP | |
| SCHEMBL6987232 | 0.85 | BMP1 (0.37) | BMP1MMP2PSMB5RENAPP | |
| SCHEMBL6982715 | 0.82 | CYP1A2 (0.37) | MMP1MMP13MMP3 | |
| SCHEMBL6983470 | 0.81 | BMP1 (0.39) | BMP1MMP2PSMB5RENMMP1 | |
| SCHEMBL6986871 | 0.80 | MMP1 (0.37) | MMP2RENMMP1MMP13MMP3 | |
| SCHEMBL6982858 | 0.80 | MMP1 (0.38) | RENMMP1MMP13 | |
| SCHEMBL6982401 | 0.80 | APP (0.37) | BMP1MMP2MMP1MMP13MMP3 | |
| SCHEMBL6986904 | 0.79 | REN (0.36) | BMP1MMP2RENMMP1MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1089964-B1 | HYDRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2003-10-29 | — | — | EP | disclosed |
| US-6239151-B1 | TREATMENT OF INFLAMMATORY AND AUTOIMMUNE DISEASES, OSTEOARTHRITIS, RESPIRATORY DISEASES, TUMORS, CACHEXIA, CARDIOVASCULAR DISEASES, FEVER, HAEMORRHAGE AND SEPSIS, HYDRAZINE DERIVATIVES, | HOFFMANN-LA ROCHE INC. | 2001-05-29 | — | — | US | disclosed |