SCHEMBL6981805

SCHEMBL6981805

CCC(CSCc1ccccc1)Nc1nc(Cl)nc(C(F)(F)F)n1

nearest known ligand 0.41

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.36
CCNE2 O96020 1/20 0.33
CDK4 P11802 1/20 0.33
CCND1 P24385 1/20 0.33
CCNE1 P24864 1/20 0.33
CDK2 P24941 1/20 0.33
CDK1 P06493 1/20 0.33
KCNH3 Q9ULD8 1/20 0.33
TLR7 Q9NYK1 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7613516 0.83 ALDH1A1 (0.38) ALDH1A1CDK1KCNH3
SCHEMBL8084534 0.77 ALDH1A1 (0.50) ALDH1A1KCNH3TLR7
SCHEMBL7960038 0.74 SCN9A (0.41) ALDH1A1TLR7
SCHEMBL7615508 0.73 IDH1 (0.34) ALDH1A1CDK4CCND1CCNE1CDK2
SCHEMBL7676182 0.70 HTR2C (0.35) ALDH1A1
SCHEMBL6981801 0.67 LMNA (0.35) ALDH1A1TLR7
SCHEMBL7615960 0.67 CDK1 (0.32) ALDH1A1CDK4CCND1CCNE1CDK2
SCHEMBL7751751 0.65 HTR7 (0.37)
SCHEMBL7954573 0.64 KCNH2 (0.41) ALDH1A1
SCHEMBL14525778 0.61 CYP2D6 (0.46)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1037882-B1 SUBSTITUTED 2,4-DIAMINO-1,3,5-TRIAZINES BAYER CROPSCIENCE AG (DE) 2003-11-05 EP disclosed
EP-1037882-A1 SUBSTITUTED 2,4-DIAMINO-1,3,5-TRIAZINES BAYER AG (DE) 2000-09-27 EP disclosed
WO-1999029677-A1 SUBSTITUTED 2,4-DIAMINO-1,3,5-TRIAZINES BAYER AKTIENGESELLSCHAFT (DE) 1999-06-17 WO disclosed