Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP26A1 | O43174 | 4/20 | 0.38 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.38 |
| ▸ | NAMPT | P43490 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6987473 | 0.94 | CYP26A1 (0.39) | CYP26A1NAMPTNPC1SMN1; SMN2RAB9A | |
| SCHEMBL6981905 | 0.89 | HRH4 (0.39) | CYP26A1NAMPTNPC1RAB9A | |
| SCHEMBL6986414 | 0.89 | CYP26A1 (0.39) | CYP26A1NAMPTNPC1SMN1; SMN2RAB9A | |
| SCHEMBL6987187 | 0.85 | TBXAS1 (0.41) | ADAM17NAMPTCYP3A4CYP2D6 | |
| SCHEMBL6985273 | 0.82 | ADAM17 (0.59) | ADAM17CYP3A4CYP2D6 | |
| SCHEMBL6982700 | 0.79 | MMP1 (0.42) | CYP3A4CYP2D6 | |
| SCHEMBL6981814 | 0.79 | MMP1 (0.42) | CYP3A4CYP2D6 | |
| SCHEMBL7816201 | 0.78 | MMP1 (0.44) | CYP3A4CYP2D6 | |
| SCHEMBL6980338 | 0.74 | ADAM17 (0.54) | ADAM17CYP3A4CYP2D6 | |
| SCHEMBL6984204 | 0.71 | ADAM17 (0.64) | ADAM17 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1089964-B1 | HYDRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2003-10-29 | — | — | EP | disclosed |
| US-6239151-B1 | TREATMENT OF INFLAMMATORY AND AUTOIMMUNE DISEASES, OSTEOARTHRITIS, RESPIRATORY DISEASES, TUMORS, CACHEXIA, CARDIOVASCULAR DISEASES, FEVER, HAEMORRHAGE AND SEPSIS, HYDRAZINE DERIVATIVES, | HOFFMANN-LA ROCHE INC. | 2001-05-29 | — | — | US | disclosed |