Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | ADAMTS5 | Q9UNA0 | 3/20 | 0.37 |
| ▸ | WDR91 | A4D1P6 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | CYP51A1 | Q16850 | 1/20 | 0.35 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.34 |
| ▸ | CXCR3 | P49682 | 3/20 | 0.34 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
| ▸ | ACACB | O00763 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7135238 | 0.81 | ADRA1B (0.44) | ACHEALDH1A1 | |
| SCHEMBL6986741 | 0.81 | MTNR1A (0.44) | ALDH1A1TSHRNPSR1 | |
| SCHEMBL6983790 | 0.79 | KMT2A (0.39) | L3MBTL1ALDH1A1 | |
| SCHEMBL6986746 | 0.78 | SMN1; SMN2 (0.41) | L3MBTL1ALDH1A1 | |
| SCHEMBL6983282 | 0.78 | LMNA (0.45) | L3MBTL1TSHR | |
| SCHEMBL6984357 | 0.77 | ALDH1A1 (0.43) | L3MBTL1ALDH1A1 | |
| SCHEMBL4875116 | 0.76 | ADAMTS5 (0.43) | EPHX2ADAMTS5WDR91SIGMAR1GAA | |
| SCHEMBL6982527 | 0.75 | NPC1 (0.41) | GAAALDH1A1 | |
| SCHEMBL6985492 | 0.74 | POLB (0.38) | L3MBTL1ALDH1A1 | |
| SCHEMBL6985464 | 0.74 | LMNA (0.36) | ADAMTS5L3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1289965-A1 | SUBSTITUTED 1-AMINOALKYL-LACTAMS AND THEIR USE AS MUSCARINIC RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2003-03-12 | — | — | EP | disclosed |
| WO-2001090081-A1 | SUBSTITUTED 1-AMINOALKYL-LACTAMS AND THEIR USE AS MUSCARINIC RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2001-11-29 | — | — | WO | disclosed |