Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP3 | P08254 | 14/20 | 0.45 |
| ▸ | MMP1 | P03956 | 12/20 | 0.45 |
| ▸ | MMP9 | P14780 | 9/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | MMP2 | P08253 | 7/20 | 0.35 |
| ▸ | MMP14 | P50281 | 1/20 | 0.35 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.35 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.35 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.35 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.35 |
| ▸ | MMP8 | P22894 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6981813 | 0.82 | PLA2G4A (0.39) | MMP3MMP1MMP9MMP2MMP8 | |
| SCHEMBL7539010 | 0.62 | MMP3 (0.54) | MMP3MMP1MMP9MMP2MMP14 | |
| SCHEMBL6985184 | 0.62 | MMP8 (0.40) | MMP3MMP1TSHRMMP2MMP8 | |
| SCHEMBL5196301 | 0.60 | HDAC3 (0.63) | MMP3MMP1MMP9TSHRMMP2 | |
| SCHEMBL27815785 | 0.60 | HDAC3 (0.56) | MMP8 | |
| SCHEMBL19438906 | 0.60 | GRIK1 (0.67) | MMP3MMP1MMP9MMP2MMP8 | |
| SCHEMBL28174700 | 0.59 | HDAC1 (0.60) | — | |
| SCHEMBL9580577 | 0.59 | GRIK1 (0.53) | MMP3MMP1MMP2 | |
| Propane SCHEMBL8092945 | 0.58 | MAOA (0.74) | — | |
| SCHEMBL12622729 | 0.58 | HDAC1 (0.62) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1089964-B1 | HYDRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2003-10-29 | — | — | EP | disclosed |
| US-6239151-B1 | TREATMENT OF INFLAMMATORY AND AUTOIMMUNE DISEASES, OSTEOARTHRITIS, RESPIRATORY DISEASES, TUMORS, CACHEXIA, CARDIOVASCULAR DISEASES, FEVER, HAEMORRHAGE AND SEPSIS, HYDRAZINE DERIVATIVES, | HOFFMANN-LA ROCHE INC. | 2001-05-29 | — | — | US | disclosed |
| EP-1089964-A1 | HYDRAZINE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2001-04-11 | — | — | EP | disclosed |
| WO-2000000465-A1 | HYDRAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2000-01-06 | — | — | WO | disclosed |