Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G4A | P47712 | 1/20 | 0.39 |
| ▸ | MMP1 | P03956 | 7/20 | 0.37 |
| ▸ | MMP3 | P08254 | 7/20 | 0.37 |
| ▸ | MMP9 | P14780 | 4/20 | 0.36 |
| ▸ | HMOX2 | P30519 | 1/20 | 0.35 |
| ▸ | MMP2 | P08253 | 1/20 | 0.35 |
| ▸ | MMP8 | P22894 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6982082 | 0.82 | MMP3 (0.45) | MMP1MMP3MMP9MMP2MMP8 | |
| SCHEMBL6984379 | 0.79 | CYP19A1 (0.35) | HMOX2 | |
| SCHEMBL27454770 | 0.75 | HMOX2 (0.43) | HMOX2 | |
| SCHEMBL27453235 | 0.65 | ALDH1A1 (0.43) | HMOX2 | |
| SCHEMBL7816193 | 0.65 | CTSS (0.35) | HMOX2MMP8 | |
| SCHEMBL8804388 | 0.64 | TBXAS1 (0.59) | HMOX2 | |
| SCHEMBL6980808 | 0.64 | MMP3 (0.34) | MMP1MMP3MMP9MMP2MMP8 | |
| Hydrochloric Acid SCHEMBL9996084 | 0.63 | TBXAS1 (0.61) | HMOX2 | |
| SCHEMBL410597 | 0.61 | HMOX2 (0.61) | HMOX2 | |
| SCHEMBL10824518 | 0.61 | CYP24A1 (0.49) | MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1089964-B1 | HYDRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2003-10-29 | — | — | EP | disclosed |
| US-6239151-B1 | TREATMENT OF INFLAMMATORY AND AUTOIMMUNE DISEASES, OSTEOARTHRITIS, RESPIRATORY DISEASES, TUMORS, CACHEXIA, CARDIOVASCULAR DISEASES, FEVER, HAEMORRHAGE AND SEPSIS, HYDRAZINE DERIVATIVES, | HOFFMANN-LA ROCHE INC. | 2001-05-29 | — | — | US | disclosed |
| EP-1089964-A1 | HYDRAZINE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2001-04-11 | — | — | EP | disclosed |
| WO-2000000465-A1 | HYDRAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2000-01-06 | — | — | WO | disclosed |