Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | KCNA5 | P22460 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | BCL2 | P10415 | 2/20 | 0.42 |
| ▸ | BCL2L1 | Q07817 | 2/20 | 0.42 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.42 |
| ▸ | EDNRA | P25101 | 1/20 | 0.42 |
| ▸ | S1PR1 | P21453 | 3/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4527403 | 0.88 | KMT2A (0.48) | KMT2AKCNA5ALDH1A1ADAM17KCNH2 | |
| SCHEMBL698959 | 0.74 | KCNA5 (0.71) | KMT2AKCNA5ALDH1A1KCNH2MCL1 | |
| Acetic Acid SCHEMBL697091 | 0.73 | NR3C1 (0.56) | KMT2AKCNA5POLBL3MBTL1MEN1 | |
| SCHEMBL698228 | 0.72 | KCNA5 (0.64) | KMT2AKCNA5ALDH1A1KCNH2MCL1 | |
| SCHEMBL1287300 | 0.72 | MAPT (0.57) | KMT2AKCNA5ALDH1A1LMNAS1PR1 | |
| SCHEMBL1287270 | 0.72 | MAPT (0.57) | KMT2AKCNA5ALDH1A1LMNAS1PR1 | |
| SCHEMBL10711865 | 0.67 | S1PR1 (0.47) | ALDH1A1S1PR1ATML3MBTL1CYP1A2 | |
| SCHEMBL3449927 | 0.66 | S1PR1 (0.78) | KMT2AS1PR1CYP2D6CYP2C19MEN1 | |
| SCHEMBL4413684 | 0.66 | ALDH1A1 (0.44) | KMT2AALDH1A1KDM4EPOLBMCL1 | |
| SCHEMBL8839630 | 0.66 | MMP2 (0.63) | MMP2MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2423190-A1 | Compounds Exhibiting PGD 2 Receptor Antagonism | Shionogi&Co., Ltd. (JP) | 2012-02-29 | — | — | EP | disclosed |
| US-20090258922-A1 | COMPOUND EXHIBITING PGD2 RECEPTOR ANTAGONIST | SHIONOGI & CO., LTD. | 2009-10-15 | — | — | US | disclosed |
| US-7534897-B2 | Indole arylsulfonaimide compounds exhibiting PGD 2 receptor antagonism | SHIONOGI & CO., LTD. (JP) | 2009-05-19 | — | — | US | disclosed |
| US-20050171143-A1 | Compound exhibiting pgd 2 receptor antagonism | SHIONOGI & CO., LTD. (JP) | 2005-08-04 | — | — | US | disclosed |
| EP-1505061-A1 | COMPOUND EXHIBITING PGD 2 RECEPTOR ANTAGONISM | SHIONOGI & CO., LTD. (JP) | 2005-02-09 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090258922-A1 | COMPOUND EXHIBITING PGD2 RECEPTOR ANTAGONIST | CYSLTR2, CYSLTR1, HRH2 | KMT2A 2023/4885KCNA5 2720/4885ALDH1A1 1713/4885 |
| US-20050171143-A1 | Compound exhibiting pgd 2 receptor antagonism | CYSLTR2, CYSLTR1, HRH2 | KMT2A 2134/4885KCNA5 2974/4885ALDH1A1 1732/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.