Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2RL3 | Q96RI0 | 8/20 | 0.49 |
| ▸ | APP | P05067 | 7/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | ILK | Q13418 | 2/20 | 0.36 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.36 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.36 |
| ▸ | AXL | P30530 | 1/20 | 0.35 |
| ▸ | GFER | P55789 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6979539 | 0.93 | F2RL3 (0.48) | F2RL3ILK | |
| SCHEMBL6976230 | 0.81 | PTGS2 (0.49) | F2RL3APP | |
| SCHEMBL6982699 | 0.77 | F2RL3 (0.43) | F2RL3APPMAOBILKCCNE1 | |
| SCHEMBL6978354 | 0.75 | PTGS2 (0.49) | F2RL3 | |
| SCHEMBL6973108 | 0.70 | PTGS2 (0.51) | F2RL3 | |
| SCHEMBL6979548 | 0.69 | F2RL3 (0.42) | F2RL3APPILK | |
| SCHEMBL16710648 | 0.66 | F2RL3 (1.00) | F2RL3 | |
| SCHEMBL6974901 | 0.66 | PTGS2 (0.63) | — | |
| SCHEMBL6981808 | 0.64 | PTGS2 (0.63) | — | |
| SCHEMBL2711494 | 0.63 | KEAP1 (0.65) | F2RL3APPAXLGFER |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1006114-B1 | PYRAZOLE DERIVATIVES AND COX INHIBITORS CONTAINING THEM | GRELAN PHARMACEUTICAL CO (JP) | 2003-01-22 | — | — | EP | disclosed |
| US-6136831-A | ANTIINFLAMMATORY AGENTS, GASTROINTESTINAL AGENTS, ENZYME INHIBITORS | GRELAN PHARMACEUTICAL CO., LTD. (JP) | 2000-10-24 | — | — | US | disclosed |
| EP-1006114-A1 | PYRAZOLE DERIVATIVES AND COX INHIBITORS CONTAINING THEM | Grelan Pharmaceutical Co., Ltd. (JP) | 2000-06-07 | — | — | EP | disclosed |