Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 3/20 | 0.52 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.52 |
| ▸ | NFE2L2 | Q16236 | 3/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.35 |
| ▸ | CYP21A2 | P08686 | 1/20 | 0.35 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | NQO2 | P16083 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16962236 | 0.85 | PTGS1 (0.45) | PTGS1PTGS2NFE2L2CNR2CYP3A4 | |
| SCHEMBL5387223 | 0.84 | PTGS1 (0.39) | PTGS1PTGS2NFE2L2CNR2CYP3A4 | |
| SCHEMBL5387218 | 0.84 | PTGS1 (0.39) | PTGS1PTGS2NFE2L2CNR2CYP3A4 | |
| SCHEMBL16957514 | 0.80 | PTGS1 (0.37) | PTGS1PTGS2NFE2L2 | |
| SCHEMBL294120 | 0.77 | PTGS1 (0.44) | PTGS1PTGS2NFE2L2BACE1CYP3A4 | |
| SCHEMBL3619438 | 0.76 | TUBB1 (0.48) | PTGS1PTGS2NFE2L2CNR2CYP3A4 | |
| SCHEMBL3619434 | 0.76 | TUBB1 (0.48) | PTGS1PTGS2NFE2L2CNR2CYP3A4 | |
| SCHEMBL14634506 | 0.75 | NFE2L2 (0.74) | PTGS1PTGS2NFE2L2CYP3A4KDM4E | |
| SCHEMBL8175617 | 0.75 | NFE2L2 (0.74) | PTGS1PTGS2NFE2L2CYP3A4KDM4E | |
| SCHEMBL257117 | 0.75 | NFE2L2 (0.74) | PTGS1PTGS2NFE2L2CYP3A4KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180011405-A1 | RESIST UNDERLAYER FILM COMPOSITION, PATTERNING PROCESS, METHOD FOR FORMING RESIST UNDERLAYER FILM, AND COMPOUND FOR RESIST UNDERLAYER FILM COMPOSITION | SHIN-ETSU CHEMICAL CO., LTD. (JP) | 2018-01-11 | — | — | US | disclosed |
| EP-1957073-B1 | MEDICINAL DRUG | OTSUKA PHARMA CO LTD (JP) | 2014-04-23 | — | — | EP | disclosed |
| US-20120238750-A1 | AROMATIC COMPOUND | OTSUKA PHARMACEUTICAL CO., LTD. | 2012-09-20 | — | — | US | disclosed |
| US-20120238750-A1 | AROMATIC COMPOUND | OTSUKA PHARMACEUTICAL CO., LTD. | 2012-09-20 | — | — | US | disclosed |
| US-8236826-B2 | Diarylether derivatives as antitumor agents | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2012-08-07 | — | — | US | disclosed |
| US-8236826-B2 | Diarylether derivatives as antitumor agents | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2012-08-07 | — | — | US | disclosed |
| US-8188277-B2 | Aromatic compounds for suppressing the generation of collagen | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2012-05-29 | — | — | US | disclosed |
| US-8188277-B2 | Aromatic compounds for suppressing the generation of collagen | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2012-05-29 | — | — | US | disclosed |
| EP-1900792-B1 | Fluorine phenyl compounds for liquid crystalline mixtures | MERCK PATENT GMBH (DE) | 2010-08-04 | — | — | EP | disclosed |
| US-7767277-B2 | Fluorophenyl compounds for liquid-crystalline mixtures | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2010-08-03 | — | — | US | disclosed |
| US-7767277-B2 | Fluorophenyl compounds for liquid-crystalline mixtures | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2010-08-03 | — | — | US | disclosed |
| US-20100004438-A1 | DIARYLETHER DERIVATIVES AS ANTITUMOR AGENTS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2010-01-07 | — | — | US | disclosed |
| US-20100004438-A1 | DIARYLETHER DERIVATIVES AS ANTITUMOR AGENTS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2010-01-07 | — | — | US | disclosed |
| US-20080132716-A1 | difluoromethyleneoxy group bridge on fluorinated biphenyl and fluorinated phenyl group; electro-optical displays; high dielectric anisotropy, high clearing point and low rotational viscosity; photochemically stable, heat resistance; chemical intermediates | MERCK PATENT GMBH | 2008-06-05 | — | — | US | disclosed |
| US-20080132716-A1 | difluoromethyleneoxy group bridge on fluorinated biphenyl and fluorinated phenyl group; electro-optical displays; high dielectric anisotropy, high clearing point and low rotational viscosity; photochemically stable, heat resistance; chemical intermediates | MERCK PATENT GMBH | 2008-06-05 | — | — | US | disclosed |
| EP-1900792-A1 | Fluorine phenyl compounds for liquid crystalline mixtures | Merck Patent GmbH (DE) | 2008-03-19 | — | — | EP | disclosed |
| US-20070270422-A1 | Aromatic Compounds | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2007-11-22 | — | — | US | disclosed |
| US-20070270422-A1 | Aromatic Compounds | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2007-11-22 | — | — | US | disclosed |
| EP-1320529-A1 | QUINOLINE DERIVATIVES AS ANTIBACTERIALS | SMITHKLINE BEECHAM PLC (GB) | 2003-06-25 | — | — | EP | disclosed |
| WO-2002024684-A1 | QUINOLINE DERIVATIVES AS ANTIBACTERIALS | SMITHKLINE BEECHAM P.L.C. (GB) | 2002-03-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120238750-A1 | AROMATIC COMPOUND | CBR1, CBR3, CYP1A1 | PTGS1 2343/4885PTGS2 3718/4885NFE2L2 920/4885 |
| US-20100004438-A1 | DIARYLETHER DERIVATIVES AS ANTITUMOR AGENTS | ROS1, CBR1, CBR3 | PTGS1 298/4885PTGS2 1232/4885NFE2L2 598/4885 |
| US-20080132716-A1 | difluoromethyleneoxy group bridge on fluorinated biphenyl and fluorinated phenyl group; electro-optical displays; high dielectric anisotropy, high clearing point and low rotational viscosity; photochemically stable, heat resistance; chemical intermediates | FLNB, FLNA, BRAF | PTGS1 3265/4885PTGS2 3425/4885NFE2L2 1238/4885 |
| US-20070270422-A1 | Aromatic Compounds | COL1A1, COL2A1, COL14A1 | PTGS1 711/4885PTGS2 1666/4885NFE2L2 888/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.