Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | ATM | Q13315 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6984877 | 0.89 | ADAM17 (0.58) | ADAM17 | |
| Hydrochloric Acid SCHEMBL6978489 | 0.88 | ADAM17 (0.57) | ADAM17 | |
| SCHEMBL6948137 | 0.84 | ADAM17 (0.55) | ADAM17 | |
| SCHEMBL6948147 | 0.84 | ADAM17 (0.55) | ADAM17 | |
| SCHEMBL6944663 | 0.82 | ADAM17 (0.56) | ADAM17MAPTMAPK1KMT2AATM | |
| SCHEMBL6984054 | 0.81 | ADAM17 (0.42) | ADAM17 | |
| SCHEMBL6986274 | 0.81 | ADAM17 (0.52) | ADAM17MAPTMAPK1KMT2AATM | |
| SCHEMBL7935009 | 0.76 | ADAM17 (0.76) | ADAM17 | |
| SCHEMBL6220493 | 0.74 | ADAM17 (0.48) | ADAM17MAPTMAPK1KMT2AATM | |
| SCHEMBL6220496 | 0.74 | ADAM17 (0.48) | ADAM17MAPTMAPK1KMT2AATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1089964-B1 | HYDRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2003-10-29 | — | — | EP | disclosed |
| US-6239151-B1 | TREATMENT OF INFLAMMATORY AND AUTOIMMUNE DISEASES, OSTEOARTHRITIS, RESPIRATORY DISEASES, TUMORS, CACHEXIA, CARDIOVASCULAR DISEASES, FEVER, HAEMORRHAGE AND SEPSIS, HYDRAZINE DERIVATIVES, | HOFFMANN-LA ROCHE INC. | 2001-05-29 | — | — | US | disclosed |
| EP-1089964-A1 | HYDRAZINE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2001-04-11 | — | — | EP | disclosed |
| WO-2000000465-A1 | HYDRAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2000-01-06 | — | — | WO | disclosed |